Abbott Laboratories Corporation

Abbott Laboraotries

Lynn M Codacovi

Daniel W Norbeck

Dale J Kempf

Hing L Sham

Steven J Wittenberger

Jacob J Plattner

Chen Zhao

Phillip G Mattingly

Christopher J Welch

Steven C Kuemmerle

John W Erickson

Theresa L Lane

William D Garner

Suzanne M Delby

A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.

Intermediates of retroviral protease inhibiting compounds

Retroviral protease inhibiting compounds

A retroviral protease inhibiting compound of the formula

A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation Of the retroviral protease inhibitors.

The current invention is a method, kit and reagents for detecting cobalamins in a sample. The method involves introducing into the sample a first conjugate of a latex or latex-like solid phase linked to affinity purified intrinsic factor with a first linking group at least three angstroms long. The first conjugate and the bound cobalamins in the sample are then exposed to a second conjugate of a cobalamin linked to a detectable enzyme to produce second conjugate bound to first conjugate and unbound second conjugate. The enzyme activity associated either with the solid phase first conjugate or the unbound second conjugate is then detected. By linking affinity purified intrinsic factor to a latex or latex-like solid phase with a first linking group at least three angstroms long, an exzyme assay can be performed which detects levels of cobalamins in patient samples within or below normal ranges found in such samples.

Assay for cobalamins

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Antioch, IL, United States of America

Lynn M Codacovi