Mallinckrodt Medical, Inc.

Lynn A deLearie

Dennis A Moore

David H White

William P Cacheris

Raghavan Rajagopalan

Muthunadar P Periasamy

Youlin Lin

Steven R Woulfe

T Jeffrey Dunn

Max D Adams

Wayne H Lin

Processes for manufacturing diethylenetriaminepentaacetic acid ('DTPA') bis(amide) magnetic resonance imaging ('MRI') agents are disclosed. Specifically, processes for manufacturing [N,N'-Bis[N-(2-methoxyethyl)carbamoylmethyl]diethylenetriamine-N,N',N'-tri acetato]gadolinium(III) are disclosed.

Process for manufacturing DTPA-bis amide magnetic resonance imaging

Methods and compositions are disclosed for enhancing .sup.19 F magnetic resonance imaging which utilize .sup.19 F magnetic resonance contrast media having enhanced .sup.19 F relaxivity. Fluorine-containing compounds having enhanced .sup.19 F relaxation properties resulting from direct association with an unpaired spin are disclosed. The fluorine-containing compound is associated with the unpaired spin by covalent attachment of a stable free radical, by complexation of a fluorinated complexing agent with a paramagnetic metal ion, or by salt formation or charge neutralization of a paramagnetic ion.

19F magnetic resonance imaging agents which include a nitroxide moiety

Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention include stable hydrophilic free radicals having a hydrophilic moiety, such as polyhydroxyalkyl groups and heterocyclic amino-alcohols such as dihydroxypyrrolidine, dihydroxypiperidine, and trihydroxypiperidine, and a stable free radical moiety, such as a nitroxide, phenoxy, or phenoxazinyl free radical moiety.

Hydrophilic free radicals for magnetic resonance imaging

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University City, MO, United States of America

Lynn A deLearie