University of California

Other

Virginia Tech Intellectual Properties Inc

Synaptic Research, LLC

Lynette B Corbeil

Gerhardt G Schurig

Stephen M Boyle

Ramesh Vemulapalli

Nammalwar Srirnaganathan

Silvio Cravero

George A Oyler

Julian N Rosenberg

Roshan Shrestha

Jerry D Sanders

Aubrey Davis

Elizabeth J Ziegler

Mark Hildebrand

Rachel Schrier

This invention provides diatom-based vaccines.

Diatom-based vaccines

This invention relates to an over-expressing homologous antigen vaccine, a method of producing the same, and use of the vaccine for prophylaxis or treatment of vertebrates at risk of or suffering from disease caused by a pathogenic micro-organism. The vaccine is an attenuated or avirulent pathogenic micro-organism that over-expresses at least one homologous antigen encoded by at least one gene derived from the pathogenic micro-organism, and may also express a heterologous antigen.

Over-expressing homologous antigen vaccine and a method of making the same

The present invention provides a method for protecting cattle from diseases such as septicemia, pneumonia or abortion by immunizing them with an vaccine. Provided are natural isolates of strains that have one or more important features of such vaccine, including, sensitivity to killing in complement-containing bovine serum, lack of expression of immunoglobulin binding proteins, expression of protective antigens and a reduction in the release of endotoxin during growth. Vaccines using having these and other features also can be prepared from natural isolates of asymptomatic carriers or from pathogenic organisms by recombinant DNA techniques.

Vaccine based on attenuated Haemophilus somnus

Over-expressing homologous antigen vaccine and a method of making the

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San Diego, CA, United States of America

Lynette B Corbeil