Colgate Palmolive Company

The Forsyth Institute

Lyndsay Schaeffer-Korbylo

Gregory Szewczyk

Laurence Du-Thumm

Michael Prencipe

Harsh Mahendra Trivedi

Stanislav Jaracz

Lisa Manus

Betty Won

Evangelia Arvanitidou

Steven W Fisher

Yun Xu

Andre Morgan

Davide Miksa

Ravi Subramanyam

Venda Porter Maloney

Lynette Anne Zaidel

Richard J Sullivan

Kevin Mark Kinscherf

Carl Myers

Stacey Lavender

Xiao Yi Huang

Jason Nesta

Andrei Potanin

David Santos

Christine Cuiule

Yanan Hu

Jorge Frias-Lopez

Ralph Peter Santarpia Iii

Evangelia S Arvanitidou

Andre Michelle Morgan

Zhiqiang Lui

Laurence Du Thumm

Andre' Michelle Morgan

Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.

Oral care compositions containing deoxy sugar antimetabolites

Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.

Dentifrice composition comprising zinc oxide and zinc citrate

An oral care composition comprising a surfactant having formula [R(OCH)OSO]M wherein R is a saturated or unsaturated alkyl group with an alkyl chain length of 8 to 30 carbon atoms; x is from 0 to 10; and M is a divalent metal cation selected from zinc cations, copper cations and stannous cations is provided.

Oral care compositions

Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.

Bioavailability of metal ions

Disclosed herein are dentifrices comprising a zinc amino acid complex together with soluble phosphate salts. Methods of making and using the dentifrices are also provided.

Dentifrice compromising zinc-amino acid complex and phosphates

The disclosure provides oral care compositions comprising zinc ions and citrate ions with molar ratios which unexpectedly high zinc bioavailability, together with methods of preparing and using the same.

Metal salt compositions

Dentifrice compositions comprising zinc oxide and zinc citrate

Dentifrice Comprising Zinc-Amino Acid Complex and Phosphates

Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.

Oral care compositions comprising zinc amino acid halides

Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.

Oral care composition

An in vitro method for determining the bioavailability of zinc (II) ions from an oral care composition comprises: providing a sample comprising, the oral care composition; contacting the sample with a biorelevant substrate, separating the biorelevant substrate from the sample, contacting the biorelevant substrate with an indicator under conditions selected such that the indicator is capable of reacting with zinc (II) ions, and determining a light absorbance of the indicator. The indicator is zincon or a salt thereof. The method is useful for estimating the ability of an oral care composition to deliver therapeutically-active zinc (II) ions to the oral cavity. Also provided is the use of zincon and a biorelevant substrate in vitro to determine the bioavailability of zinc (II) ions from an oral care composition comprising, a zinc source.

Determining the bioavailability of zinc (II) ions

Described herein are oral care compositions comprising an effective amount of an enzyme cocktail, wherein the enzyme cocktail comprises an alkaline protease and a second enzyme selected from cellulose, &#x3b1;-glucanase, and combinations thereof, in an orally acceptable carrier, together with methods of making and using the same.

Described herein are oral care compositions comprising (i) an orally acceptable gallium salt and (ii) a basic amino acid polymer, in amounts effective to disrupt biofilm; and methods of making and using the same.

Oral care compositions and methods are described in which the composition includes a chalcone color change component, which may be phenyl-3-methoxy-4-hydroxystyryl ketone. The color change component is induced to change colors by addition of saliva and/or by a change in pH of the composition. The composition and methods provide benefits including providing visual cues to the user.

Color change of chalcone-containing oral care formulations

Described herein are compositions comprising a quinone and one or more antibacterial agents, and methods of preparing and using the same.

Growing community of inventors

Flemington, NJ, United States of America

Lyndsay Schaeffer-Korbylo