Regeneron Pharmaceuticals, Inc.

Lyndon Mitnaul

Lori C Morton

Dan Chalothorn

Lynn Macdonald

Yajun Tang

Nicole M Alessandri-Haber

Daria Zamolodchikov

Cristopher Van Hout

KehDih Lai

Harikiran Nistala

Anthony Marcketta

Non-human animal genomes, non-human animal cells, and non-human animals comprising a humanized coagulation factor XII (F12) locus and methods of making and using such non-human animal genomes, non-human animal cells, and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized F12 locus express a human coagulation factor XII protein or a chimeric coagulation factor XII protein, fragments of which are from human coagulation factor XII. Methods are provided for using such non-human animals comprising a humanized F12 locus to assess in vivo efficacy of human-coagulation-factor-XII-targeting reagents such as nuclease agents designed to target human F12. A short isoform of F12 that is produced locally in the brain, and methods of using the short isoform, are also provide.

Non-human animals comprising a humanized coagulation factor 12 locus

The present disclosure provides methods of treating subjects having increased serum glucose level and/or hyperglycemia, methods of identifying subjects having an increased risk of developing increased serum glucose level and/or hyperglycemia, and methods of detecting human Solute Carrier Family 39 Member 5 variant nucleic acid molecules and variant polypeptides.

Treatment of hyperglycemia with solute carrier family 39 member 5 (SLC39A5) inhibitors

The present invention provides monoclonal antibodies that bind to the Factor XII (FXII) protein, and methods of use thereof. In various embodiments of the invention, the antibodies are fully human antibodies that bind to FXII and to the activated form of FXII (FXIIa). In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing FXII activity, thus providing a means of treating or preventing a disease, disorder or condition associated with thrombosis in humans.

Anti-factor XII/XIIa antibodies and uses thereof

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Piscataway, NJ, United States of America

Lyndon Mitnaul