Elektrofi, Inc.

Massachusetts Institute of Technology

Lyndon Fitzgerald Charles, Jr

Paul Brown

Chase Spenser Coffman

Lisa Liu

Daniel Benjamin Dadon

Chaitanya Sudrik

Sadiqua Shadbar

Dale Arlington Thomas, Iii

Cory Robinson

Elazer Reuven Edelman

Natalie Artzi

Shimon Unterman

James W Ivey

Tyler L Carter

Shankul Vartak

Sara Elaine Strecker

Yi Tang

The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof

The invention provides methods for the preparation of particles including one or more agents, e.g., therapeutic or diagnostic agents. The particles can be formed by creating droplets of a first liquid, e.g., including an agent, and removing the first liquid, e.g., through its dispersal in a second liquid and/or evaporation, to solidify the droplets. Advantageously, the process of forming the particles does not significantly alter the structure or activity of the agents and may enhance the stability of the agents. For example, the particles may be stored for long periods of time without significant loss of activity, and in some embodiments, without the need for refrigeration. These particles may be used to generate stabilized pharmaceutical compositions for storage or other logistical purposes, pharmaceutical suspensions, pharmaceutical powder formulations (e.g., inhalable powders, injectable powders), creams or other topical pastes, nutraceuticals, or cosmetics.

Formation of particles including agents

The present disclosure relates to compositions and methods that enable the formation of pharmaceutically relevant particles that can be used for therapy. In particular, the methods disclosed herein allow the controlled formation of circular particles having low internal void spaces comprising bioactive therapeutic agents.

Particle formation and morphology

The present disclosure provides compositions and methods for treating a disease or condition in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising a plurality of particles comprising at least one therapeutic biologic suspended in a pharmaceutically acceptable liquid carrier.

Compositions and methods for the delivery of therapeutic biologics for treatment of disease

Electrospraying formation of particles including agents

Provided herein are methods for treating, adhering, or sealing biological tissue with a material, such as a hydrogel, that may include phyllosilicate nanoplatelets. The phyllosilicate nanoplatelets can have a high aspect ratio, a low aspect ratio, or be a mixture of high aspect ratio and low aspect ratio nanoplatelets. Drug releasing compositions and kits also are provided herein.

Hydrogel composites, compositions, and methods

Growing community of inventors

Somerville, MA, United States of America

Lyndon Fitzgerald Charles, Jr