Corixa Corporation

Alligator Bioscience Ab

Aptevo Research and Development LLC

Emergent Product Development Seattle,llc

Aptevo Reserch and Development LLC

Lynda Misher

Steven G Reed

Tony Nick Frudakis

John M Smith

Davin C Dillon

Marc W Retter

Christina Furebring

Peter Ellmark

Laura Von Schantz

Sara Fritzell

Laura Varas

David Bienvenue

Gabriela Hernandez-Hoyos

Anna Sall

Yasir A W Skeiky

Danielle Mitchell

Susan L Harlocker

Aijun Wang

Peter Robert Baum

Samuel X Li

Craig H Day

Peter Armstrong Thompson

Alan Keith Lofquist

Ta Deng

Danielle Van Citters

Gregory A Spies

The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB. The molecules may have at least one humanized 5T4-binding or 4-1BB-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to 5T4 or 4-1BB may have a second binding domain that binds to another target. The molecules may bind both 5T4-expressing cells and a cell-surface molecule expressed by an effector cell to enhance effector cell activation, proliferation, survival and/or effector-cell mediated cytotoxicity. The disclosure also provides pharmaceutical compositions comprising the 5T4-binding or 4-1BB-binding polypeptide or protein molecules, nucleic acid molecules encoding these polypeptides and methods of making and using these molecules.

Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods

Oncofetal antigen binding proteins and related compositions and methods

A binding domain polypeptide and fusion proteins thereof that recognize an IL6/IL6 receptor complex, as well as compositions and methods of use thereof.

Antagonists of IL-6

Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.

Compositions and methods for the therapy and diagnosis of breast cancer

Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

Compositions and methods for the treatment and diagnosis of breast cancer

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Seattle, WA, United States of America

Lynda Misher