Syntex (u.s.a.) Inc.

Pfizer Corporation

Pharmacia Corporation

Lynda M Sanders

Brian H Vickery

Eric J Benjamin

Cherng-chyi Fu

Thomas R Tice

Danny H Lewis

John S Kent

Abraham Domb

Ramon A Burns, Jr

Pharmaceutical compositions of biologically active polypeptides in powder form suitable for nasal administration, comprising a therapeutically effective amount of a biologically active polypeptide and a water-soluble polysaccharide.

Intranasal administration of polypeptides in powdered form

Intranasal administration of LHRH polypeptides in powdered form

An implantable polymeric delivery system for the controlled and continuous administration of an LHRH agonist which comprises a silicone elastomer matrix in which is dispersed about 30 to about 42 weight percent of water-soluble particulate phase containing an LHRH analog or a pharmaceutically acceptable salt thereof.

Delivery systems for the controlled administration of LHRH analogs

This invention concerns novel, delayed/sustained release devices and compositions, including methods of their manufacture and use. The compositions include macromolecules, particularly polypeptide pharmaceuticals, and an initially partially-hydrated, non-biodegradable, hydrogel rate-limiting membrane.

Delayed/sustained release of macromolecules

This invention concerns novel sustained release microcapsule compositions comprising water-soluble, hormonally active polypeptides and, optionally, a polymer hydrolysis modifying agent encapsulated in a biocompatible, biodegradable polymer.

Microencapsulation of water soluble active polypeptides

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Palo Alto, CA, United States of America

Lynda M Sanders