University System of Maryland

The General Hospital Corporation

Pohang University of Science and Technology Foundation

Lyle David Isaacs

Da Ma

Gaya Hettiarachchi

Volker Briken

Duc M Nguyen

Matthias Eikermann

Kimoon Kim

Narayanan Selvapalam

Joseph F Cotten

Young Ho Ko

Hyunuk Kim

Ben Zhang

Sang-Kyu Park

Cristina Cusin

Youngkook Kim

Simin Liu

Wei-Hao Huang

Jason Alan Lagona

Acyclic CB[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. Also provided are compositions and methods of using them for therapy or prophylaxis of a wide variety of conditions for which therapy or prophylaxis is desirable.

Molecular containers and methods of making and using same

Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.

Acyclic cucurbit[n]uril type molecular containers to treat intoxication and decrease relapse rate in substance abuse disorders

Provided are methods for reversing the effects of agents used for muscular immobilization and/or loss of consciousness and/or loss of pain perception. The method comprises administering a composition comprising acyclic CB[n]-type compounds to an individual in need of reversal of the effects of neuromuscular blocking agents and/or anesthetic agents such that the effects of the agent(s) are partially fully reversed.

Reversal of drug-induced neuromuscular block using novel molecular containers

Inverted cucurbituril compounds having at least one pair of hydrogen atoms protruding into an internal molecular cavity thereof.

Introverted CB[n] compounds

Nor-seco-type cucurbit[n]uril compounds and methylene bridged glycoluril oligomers are produced by reacting glycoluril and formaldehyde in strong organic or mineral acid at a temperature adequate to condense the reactants. These compounds are characterized by lacking &#x2014;CH&#x2014; groups rendering their internal cavities more open and, for example, more responsive to guest compounds.

Nor-seco-bis-nor-seco, tris-nor-seco, and higher nor-seco-cucurbit[n]uril compounds

Cucurbit[n]uril compounds each containing phthalhydrazide units in a macrocycle wall thereof, which compound is selected from the group consisting of CB[5], CB[6], CB[7] and CB[8] compounds, the compounds having an internal cavity which may be used to contain a guest compound.

Cucurbit [n] uril compounds and analogs, and methods of making and using the same

Growing community of inventors

Silver Spring, MD, United States of America

Lyle David Isaacs