Merck + Co., Inc.

Lydia T So

Shieh-Shung T Chen

Raymond F White

Fermentation of the microorganism Streptomyces sp. MA6966 (ATCC 55293) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields a new compound hydroxylated in the 2-butyl group which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

Antihypertensive compound and method of use thereas

Fermentation of the microorganism Actinoplanes sp. MA6559 (ATCC 53771) in the presence of the Angiotensin II (A II) receptor antagonist ##STR1## yields a new compound, hydroxylated in the 2-butyl group, which is also an A II antagonist useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.

Growing community of inventors

Maywood, NJ, United States of America

Lydia T So