De Novo Pharmaceuticals Limited

Osi Pharmaceuticals, Inc.

Lydia Saroglou

Raymond Paul Beckett

Robin Wilkes

Barry Porter

Paul Gane

Kenneth Keavey

Jac Wijkmans

Compounds of formula (I) and (IA) have antibacterial or antiprotozoal activity: formula (1) formula (2) wherein: Z represents a radical of formula N(OH)CH(&#x2550;O) or of formula C(&#x2550;O)NH(OH); Rrepresents hydrogen, methyl or trifluoromethyl, or, except when Z is a radical of formula N(OH)CH(&#x2550;O), a hydroxy or amino group; Rrepresents a radical of formula R&#x2014;(X)-(ALK)- wherein Rrepresents hydrogen, or an optionally substituted c-Calkyl, C-Calkenyl, C-Calkynyl, cycloalkyl, aryl, or heterocyclyl group, ALK represents a straight or branched divalent C-Calkylene, C-C6 ?alkenylene, or C-Calkynylene radical, and may be interrupted by one or more non-adjacent NH&#x2014;, &#x2014;O&#x2014; or S&#x2014; linkages, X represents NH&#x2014;, &#x2014;O&#x2014; or S&#x2014;, and m and n are independently 0 or 1; Rrepresents hydrogen, C-Calkyl, or benzyl; and Ris as defined in the specification.

Antimicrobial agents

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Oxford, United Kingdom

Lydia Saroglou