Institut Fur Mikrotechnik Mainz Gmbh

Other

Nexuspharma, Inc.

Boehringer Ingelheim International Gmbh

Fox Chase Cancer Center

Morphochem Aktiengesellschaft Fur Kombinatorische Chemie

R&d-biopharmaceuticals Gmbh

Ontochem Gmbh

Priaxon Ag

Universitatsklinikum Hamburg-eppendorf

Alphaptose Gmbh

Radioprotect Alphaptose Ug & Co. Kg

Dömling, Alexander

Lutz Weber

Wolfgang Ehrfeld

Vladimir Khazak

Christoph Burdack

Cedric Kalinski

Gunther Ross

Wolfgang Richter

Heinz Lehr

Erica A Golemis

Matthias Nienhaus

Frank Michel

Alexander Dömling

Stephan Kleen

Thomas Richter

Julia Diederichs

Sanjay R Menon

Cotïc Kalinski

Günther F Ross

Timo Bohme

Axel Rolf Zander

Francis Ayuk Ayuketang

Alexander Doemling

Cédric Kalinski

Guenther Ross

The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention.  Compounds of formula (I) or (Ia) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (I) or (Ia) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections.

Pyrrolidin-2-ones

The present invention relates to pharmaceutical dosage forms for topical administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases.

Topical dosage form comprising tri-substituted glycerol compounds

The invention refers to a method creating a data structure including many data elements comprising the steps of receiving multiple data elements to be stored from an input data structure, providing a continuous array in memory, allocating memory space within the continuous array for the data elements and storing the data elements in the allocated memory space. In particular, the invention refers to a method for creating a tree based dictionary from data elements received from an input structure. Moreover, it refers to a method for searching data structures including tokens by means of a tree based dictionary and a method for annotating tokens in a data structure. The invention does also refer to corresponding computer systems, software and storage media.

Methods, computer systems, software and storage media for handling many data elements for search and annotation

The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections. 

Tetrahydro-isoquinolines

A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic array of compounds, comprising known protein receptor ligands and other biologically active molecules to determine if a proposed small molecule is a functional equivalent of a receptor ligand, having therapeutic utility as a pharmaceutically relevant and useful agent either alone or in combination with other molecules. Furthermore, the invention provides for a method for the treatment of cancer comprising administering a combination of ET-18-O-CH3 and an anti-cancer agent.

[object Object]

The present invention provides a compound selected from compounds of formula I as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy. Compounds of formula (I) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events, heart valvular degenerative disease Moreover, compounds of formula (I) can be used to decrease the side effects from cytotoxic cancer agents and to treat viral infections. 

Tetrahydro-isoquinolin-1-ones for the treatment of cancer

The invention relates to novel tubulysin conjugates (e.g. of tubulysin A) and the use thereof in the treatment of cancer diseases.

Tubulysin conjugates

Isoindolone derivatives, compositions containing the same, and methods of use thereof for the treatment or prophylaxis of viral infection are disclosed.

Isoindolone compounds, compositions containing the same, and methods of use thereof for the treatment of viral infections related to the etiology of cancer

The present invention relates to new Macrocycles of formula (I) and their use for the treatment of cancer.

Thia-epothilone derivatives for the treatment of cancer

This describes a procedure for replicative fabrication and packaging of at least one microstructured molded part as one magazine/molded part composite as well as a magazine with at least one microstructured molded part as one magazine/molded part composite. The first step covers fabrication of at least one microstructured molded part using an initially closed tool which consists of at least one first and one second tool half. In the second step, both tool halves are opened, whereby the molded part remains in the first tool half. In the third step, at least the second tool half is replaced with at least one additional tool half. In the fourth step, the replicative fabrication of the magazine is carried out using the first tool half containing the molded part and the additional tool half. Finally in the fifth step, magazine and molded part are demolded simultaneously as one magazine/molded part composite. Under the invention, either the magazine or the microcomponents can be fabricated first depending on the final design of the microcomponent and magazine. This procedure, which preferably uses a 2-component injection molding process, allows the direct fabrication of several molded parts or microcomponents and their magazine packaging as one magazine/molded part composite without any after-treatment requirement, whereby different physical heights are fabricated for the magazine and microcomponents. Since the magazine connects the microcomponents only at parts of the side, bottom or face surfaces, a gripper can be used for very precise, fully automated mounting of the microcomponent.

Storage magazine for microstructured molded parts and fabrication procedure

Magazine for microstructured moulded parts and method for the production thereof

The object of the invention is to produce multipole magnetic systems that are composed of a plurality of individual magnetic components that preferably are made of rare-earth magnetic material. The invention relates to a method for producing and magazining at least one individual magnetic component, a magazine for at least one individual magnetic component by molding and for conventionally magnetizing the same. The invention further relates to a method of assembly for producing a magnetic system and to the resulting magnetic systems. The invention teaches that extremely flat multipole magnetic systems in the form of magnet rings or magnet strips and three-dimensional magnet bodies such as a magnetic scale, for example, can be produced by means of individual magnetic components that are directly adjacent to each other or are arranged at a distance by means of a molding material, for example. The magnetic systems taught by the invention are provided with a particularly high level of integration of the individual magnetic components and a uniform overall magnetization of the magnet segments which, acting as permanent magnet components, can be used in electromagnetic drives, magnetic path and angle measuring systems, magnetic couplings and valves, for example.

Method for producing and magazining individual magnetic components and the assembly thereof for producing miniaturized magnetic systems and such magnetic systems

Disclosed is a method to simplify the handling of micro-components, wherein a micro-component is initially produced on a micro-component base plate. At least the open side surfaces of the micro-component are then cast using a hardening molding material whereupon the base plate and/or the molding material covering the micro-component is removed. The magazine for at least one micro-component comprises of a disk-shaped plate encompassing the micro-component at least one its lateral surfaces is positive joint. The assembly method for micro-components includes a magazine which is configured in the form of a disk-shaped plate containing at least one micro-component which encompasses at least on one of its sides in positive fit. Said magazine is held and maintained by a retaining device, whereupon the micro-component which is to be assembled is squeezed out of the magazine and simultaneously positioned in a specific location.

Integrally cast magazine for microcomponents

Disclosed is a method to simplify the handling of micro-components, wherein a micro-component is initially produced on a micro-component base plate. At least the open side surfaces of the micro-component are then cast using a hardening moulding material whereupon the base plate and/or the moulding material covering the micro-component is removed. The magazine for at least one micro-component comprises of a disk-shaped plate encompassing the micro-component at least one its lateral surfaces is positive joint. The assembly method for micro-components includes a magazine which is configured in the form of a disk-shaped plate containing at least one micro-component which encompasses at least on one of its sides in positive fit. Said magazine is held and maintained by a retaining device, whereupon the micro-component which is to be assembled is squeezed out of the magazine and simultaneously positioned in a specific location.

Growing community of inventors

Germering, Germany

Lutz Weber