Thinxxs Microtechnology Ag

Thinxxs Microtechnology Gmbh

Boehringer Ingelheim Vetmedica Gmbh

Daktari Diagnostics, Inc.

Thinkkx Microtechnology Ag

Thinxxs Gmbh

Sanofi-a Ventis Deutschland Gmbh

Lutz Weber

Dominique M Freeman

Don Alden

Dirk Boecker

Lee Zamir

Heinz Schoeder

Matthias Kronsbein

Hannah Schmolke

Guenter Bruckmann

Aaron Oppenheimer

Rene Wirt

Michel Neumeier

Tina Röser

Andrew J Boyce

Philip Charles Walker

Zachary Jarrod Traina

Stefan Keck

Han Joachim Hartmann

Adam Casey

A flow cell having at least one storage zone connected to a duct for conducting fluid out of, into or/and through the storage zone. The duct includes a duct section which is delimited by a substrate and a film joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The film covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.

Flow cell comprising a storage zone and a duct that can be opened at a predetermined breaking point

A microfluidic flow cell for carrying out an analysis, having a substrate of synthetic material, which has cavities for the formation of channel structures and chambers, wherein the cavities are closed on one side of the substrate by a film adhesively bonded or welded to the substrate, and having a housing component that is produced with a hard and a soft component, which, on the side of the substrate facing away from the film, is connected to the substrate, completing functional sections respectively fulfilling the function of the flow cell. The housing component is formed as a multifunctional part completing more than two functional sections.

Flow cell having a housing component

A flow cell having at least one storage zone connected to a duct for conducting fluid out of, into or/and through the storage zone. The duct includes a duct section which is delimited by a substrate and a film joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The film covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall which is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.

A flow cell and a method for connecting components of a microfluidic flow cell, in particular for integrating component parts into a carrier structure of the flow cell, in which a gap is formed between the components to be connected. The gap is filled with a solvent. The material of at least one component bordering the gap dissolves in the solvent and the material completely fills the width of the gap and partially fills the height thereof after evaporation of the solvent.

Method for connecting components of a microfluidic flow cell

A microfluidic flow cell including an electrode or sensor device which is located inside the flow cell and from which at least one connecting conductor leads to an externally accessible terminal contact. The electrode or sensor device is arranged on an insulated substrate member. The connecting conductor is embedded in the substrate member. The substrate member can be inserted into an opening in the flow cell such that the electrode or sensor device is placed in the flow cell.

Microfluidic flow cell comprising an integrated electrode, and method for manufacturing same

A flow cell having at least one reservoir region containing a liquid reagent. The reservoir region is delimited by a carrier element introduced into an opening in the flow cell together with the reagent, wherein the carrier element seals off the reservoir region from the outside in a fluid-tight manner, and has a vessel and/or capillary structure holding the liquid reagent on the carrier element.

Flow cell having a reagent reservoir

A reagent reservoir for fluids, including a storage chamber connected to a duct for conducting fluid out of, into and/or through the storage chamber. The duct includes a duct section delimited by a substrate and a film joined to the substrate. The duct is sealed and is openable at a predetermined breaking point by deflecting the film. The film also delimits the storage chamber and covers a recess in the substrate which forms the duct section. A sealing wall that seals the duct and is integrally joined to the substrate is placed in the recess. The predetermined breaking point is formed by a breakable joining region between the film and edge portion of the sealing wall facing the film. The dimensions of a peripheral area of the sealing wall, which is formed in the edge portion and runs parallel to the film, determine the surface area of the joining region.

Reagent reservoir for fluids

A cartridge for analyzing a biological sample, wherein the cartridge includes a fluid system having a plurality of channels and at least one valve, wherein the valve is covered on the outside by a cover, and wherein the valve is configured to be actuated by deforming a wall of the valve.

Cartridge for testing a biological sample

A cartridge, an analysis system and a method for analyzing, in particular, a biological sample, wherein a first group having one or more valves and a second group having one or more valves can be or are actuated from different sides of the cartridge.

Cartridge, analysis system and method for testing a sample

An arrangement including a plurality of carrier elements for a reagent, which is to be introduced into a microfluidic device, in particular a flow cell, via the carrier element, and a holder receiving the plurality of carrier elements. The carrier element is fixed by positive fit in all spatial directions by the holder, keeping at least one region of the carrier element which receives the reagent clear.

Holder for reagent tray elements

A microfluidic flow cell, which has a storage space, which holds liquid reagent material and/or sample material and which is connected to an inlet channel for a fluid that transports the reagent material and/or sample material out of the storage space and to an outlet channel for the reagent material and/or sample material and the fluid. The inlet channel and the outlet channel are connected by a bypass that bypasses the storage space.

Microfluidic flow cell having a storage space that holds liquid reagent material and/or sample material

A sample carrier having a region for receiving a sample which is to be analyzed, the volume thereof being between 1-100 &#x3bc;l, and having an area for handling the sample carrier. The sample carrier is characterized by devices for the fluid-tight placement of the sample carrier together with the sample in an analysis device. An analysis device, in particular a flow cell, includes the sample carrier.

Sample carrier

A carrier element for introducing a dry substance into a cavity of a microfluidic flow cell or a chamber or cavities for interacting with a fluid, including: a plug-like body figure to be insertable into a passage of the flow cell leading to the cavity; and, a carder surface for receiving the drive substance, the carder surface being at an end of the body facing the cavity when the body is inserted in the passage.

Growing community of inventors

Zweibrücken, Germany

Lutz Weber