Other

The Scripps Research Institute

Medical Research Council

Stratagene

Bicycle Therapeutics Limited

British Technology Group Limited

Btg International Limited

Celltech Limited

Domantis Limited

Medical Research Institute

Catalyst Assets LLC

Lutz Riechmann

Gregory Paul Winter

Richard A Lerner

Joseph A Sorge

William D Huse

Herman Waldmann

Daniel Paul Teufel

David Loakes

Michael Ronald Clark

John Tite

Christian Heinis

Elise Bernard

Marina Vaysburd

Mark William Bodmer

Raymond John Owens

Geoffrey Thomas Yarranton

Peter Kristensen

Jean-Luc Jestin

John Paul Tite

The invention relates to a method for providing a multispecific peptide ligand comprising a polypeptide covalently linked to a molecular scaffold at three or more amino acid residues and capable of binding to two or more separate targets, comprising the steps of: (a) providing a first repertoire of polypeptides, each polypeptide comprising two or more reactive groups capable of covalent linkage to a molecular scaffold, and at least one loop which comprises a sequence of two or more amino acids subtended between two of said reactive groups; (b) providing a second repertoire of polypeptides as described in (a); (c) joining at least one loop of one or more members of the first repertoire to at least one loop of one or more members of the second repertoire to form at least one polypeptide comprising two loops, and (d) conjugating the composite polypeptide(s) to a molecular scaffold at at least three amino acid positions.

Multispecific peptides

The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.

Method for producing polymers having a preselected activity

Method for tapping the immunological repertoire

The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.

Selection system

An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.

Antibodies to the antigen Campath-1

Method for tapping the immunological repertiore

Methods for preparing Fv fragments which lack linking polypeptides in eukaryotic cells are provided.

Method for producing Fv fragments in eukaryotic cells

An antibody is produced, which will bind effectively with the antigen Campath-1, and which has at least one complementarity determining region of rat origin, as identified in FIG. 2, which may be combined with a range of different foreign variable domain framework regions as desired, including framework regions of human origin.

Antibodies to the antigen campath-1

Growing community of inventors

Cambridge, United Kingdom

Lutz Riechmann