Analyticon Ag Biotechnologie Pharmazie

Diagen Institut Fur Molekular-biologische, Diagnostik Gmbh

Analyticon Gesellschaft Fur Chemische Analytik Und Consulting Gmbh

Lutz Muller-Kuhrt

Andreas Immelmann

Holger Gumm

Jindrich Cinatl

Hans Wilhelm Doerr

Holger Rabenau

Kai Uwe Bindseil

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The invention relates to novel .gamma.-pyrones, .gamma.-pyridones and .gamma.-thiopyrones and their use as medicaments against viral diseases, preferably for the treatment of retroviral diseases, comprising compounds of the formula (I), in which R.sub.1 and R.sub.2 stand for hydrogen, a branched-chain or unbranched-chain C.sub.1 to C.sub.26, preferably C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.26 alkenyl or C.sub.1 to C.sub.26 alkinyl group or combinations thereof; R.sub.3 stands for a branched-chain or unbranched-chain C.sub.1 to C.sub.26 alkyl group; and R.sub.4 stands for a C.sub.3 to C.sub.26 cycloalkyl, branched-chain or unbranched-chain alkyl, alkenyl or alkinyl group. The hydrogen atoms of the methylenic group in R.sub.1, R.sub.2 and R.sub.4 may be substituted by O alkyl (C.sub.1 to C.sub.6), O acyl, O aryl, O aralkyl and alkyl (C.sub.1 to C.sub.6) groups, and in R.sub.4 also by halogenated groups, oxo groups and hydroxylic groups with double links. The elements represented by Z are independently from each other O, S or NH. ##STR1##

.gamma.-pyrones, .gamma.-pyridones, and .gamma.-thiopyrones, their use

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Berlin, Germany

Lutz Muller-Kuhrt