Bayer Aktiengesellschaft

Suddeutsche Zucker-aktiengesellschaft

Baker Aktiengesellschaft

Lutz Muller

Walter Puls

Bodo Junge

Rudiger Sitt

Hilmar Bischoff

Jurgen Stoltefuss

Hans-Peter Krause

Hans P Krause

Fred R Heiker

Delf Schmidt

Mohammad Munir

Werner Frommer

Gunther Kinast

Hubert Schiweck

Wolfgang Gau

Georg Steinle

Gunter Thomas

Uwe Keup

Ulrich Heber

The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said compounds and compositions. The subject matter of the invention is useful against diabetes, hyperlipaemia and adiposity as well as in animal nutrition.

Antidiabetic 3,4,5-trihydroxypiperidines

The invention relates to amino-cyclitol derivatives of Formula (I) and their individual anomers. Also included in the invention are processes for the manufacture of said amino-cyclitol derivatives and their individual anomers, compositions containing said amino-cyclitol derivatives or anomers; and methods for the use of said derivatives and anomers for the treatment of diabetes, adiposity or hyperlipaemia.

Medicaments containing amino-cyclitol derivatives

The invention relates to animo-cyclitol derivatives of Formula (I) and their individual anomers. Also included in the invention are processes for the manufacture of said amino-cyclitol derivatives and their individual anomers, compositions containing said amino-cyclitol derivatives or anomers; and methods for the use of said derivatives and anomers for the treatment of diabetes, adiposity or hyperlipaemia.

The invention relates to saturated aminocyclitol derivatives, as defined herein in Formula (F). Also included in the invention are methods for preparing said saturated aminocyclitol derivatives, compositions containing said saturated aminocyclitol derivatives and methods for the use of said compounds and compositions to provide inhibition of .alpha.-glycoside hydrolases.

Saturated aminocyclitol derivatives, their preparation and medicaments

Amino-cyclitol derivatives and medicaments containing them

The invention relates to 3,4,5-trihydroxypiperidine compound of Formula (I) as methods for the preparation of said compounds. Also included in the invention are compositions containing said piperidine compounds and methods for the use of said piperidine compounds and compositions. The invention further includes veterinary compositions containing said piperidine compounds and their use in animal nutrition.

N-phenoxy(or thio)hydrocarbon 3,4,5-trihydroxypiperidine derivatives,

The invention relates to .alpha.-hydroxyalkyl-3,4,5-trihydroxypiperidines defined by Formula (I), infra, and pharmaceutical compositions and medicaments containing said compounds. Also included in the invention are methods for the use of said compounds, compositions and medicaments as inhibitors of .alpha.-glucoside hydrolases; and intermediates for the compounds of said Formula (I).

2-Hydroxyalkyl-3,4,5-trihydroxy-piperidine compounds, their production

The invention relates to 1-alka-2,4-dienyl-2-hydroxymethyl-3,4,5-trihydroxypiperidine compounds which are, inter alia, potent inhibitors for .alpha.- glucoside hydrolases and effect lipid absorption. Also included in the invention are methods for the manufacture of the said compounds, compositions containing said compounds and methods for the use of said compounds and compositions.

1-Alka-2,4-dienyl-2-hydroxymethyl-3,4,5-trihydroxypiperidines as

According to the present invention inhibitors for glycoside hydrolases, and in particular glucosidase inhibitors especially saccharase inhibitors, which are active in the digestive tract are formed by culturing organisms of the family Bacillaceae, particularly by strains of the genus Bacillus. It has also been found that certain strains of organisms of the family Bacillaceae, especially strains DSM 7, DSM 704 and DSM 675 produce the antibiotic known as 1-desoxynojirimycin. The invention therefore provides a method of producing 1-desoxynojirimycin which comprises culturing a 1-desoxynojirimycin producing organism of the genus Bacillus. Inhibitors for glycoside hydrolases and the invention includes methods for producing such inhibitors, pharmaceutical compositions containing the inhibitors and methods of treatment involving the use of the inhibitors.

Inhibitors, obtained from bacilli, for glycoside hydrolases

The invention relates to N-amino-3,4,5-trihydroxypiperidines, methods for their production, compositions containing said compounds. Also included are methods for the use of said compounds and compositions.

N-Amino-3,4,5-trihydroxypiperidines, their production and their

The invention relates to 3,4,5-trihydroxypiperidines, processes for their producion, compositions containing them and methods for the use of said 3,4,5-trihydroxypiperidines and compositions containing them. The compounds and compositions of the invention are useful, inter alia, for their saccharase inhibiting activity in warm-blooded animals as well as their ability to improve feed utilization in warm-blooded and cold-blooded animals.

Saccharase inhibiting 3,4,5-trihydroxypiperidine derivatives

Animal feedstuffs employing 3,4,5-trihydroxypiperidines

Glucopyranosido-1,6-mannitol, represented by the formula: ##STR1## and a process for its preparation are provided. The glucopyranosido-1,6-mannitol is obtained by catalytically hydrogenating neutral aqueous solutions of isomaltulose and cooling the hydrogenated solution. In a second embodiment of the invention the use of the glucopyranosido-1,6-mannitol as a sugar substitute, sweetener for food or beverages, and sweetened food composition is provided.

Glucopyranosido-1,6-mannitol, a process for producing the same and its

The present invention provides amino-sugar derivatives of the general formula ##STR1## in which n and m independently of each other represent an integer from 0 to 8 and the sum n+m has a value of 0 to 8, and X designates a group --OR, --SH, --SR, --NH.sub.2, --NHR or NRR.sub.1, in which R designates an alkyl, alkenyl, cycloalkyl, aralkyl, aryl or heterocyclic radical, which can be substituted, and R.sub.1 designates an alkyl, cycloalkyl, aralkyl or aryl radical, which can be substituted, or R and R.sub.1 together with the nitrogen atom to which they are bonded, form a heterocyclic ring. It has been found that the compounds of the formula (II) are highly active inhibitors for glycoside hydrolases of the digestive tract. Also included in the invention are methods of preparing the amino-sugar derivatives of the invention, compositions containing said amino-sugar derivatives and methods for the use of said amino-sugar derivatives and compositions containing them.

Growing community of inventors

Wuppertal, Germany

Lutz Muller