Grunenthal Gmbh

Gruenenthal Gmbh

Lutz Barnscheid

Sebastian Schwier

Klaus Wening

Eric Galia

Jana Pätz

Johannes Bartholomäus

Johannes Heinrich Bartholomaeus

Marcel Haupts

Anja Geissler

Anja Geiβler

Iris Ziegler

Elisabeth Arkenau-Maric

Ulrike Bertram

Anne Faure

Filip René Irena Kiekens

Jody Firmin Marceline Voorspoels

Eugeen Marie Jozef Jans

Anja Geißler

Marc Frevel

Kornelia Griessmann

Jana Denker

Jessica Redmer

Andrea Schüessele

Stefanie Strauch

Andrea Schüssele

Udo Rüttgers

Julia Baronsky-Probst

Eugeen Marie Jans

Jody Firmin Voorspoels

Filip Rene Kiekens

Andrea Schuessele

The invention relates to a tamper-resistant tablet comprising

Tamper-resistant tablet providing immediate drug release

The invention relates to a tamper-resistant, oral pharmaceutical dosage form comprising a pharmacologically active ingredient having psychotropic action and an ethylene-vinyl acetate (EVA) polymer which provides resistance against solvent extraction, resistance against grinding, and resistance against dose-dumping in aqueous ethanol.

Tamper-resistant dosage form containing ethylene-vinyl acetate polymer

A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising

Oxidation-stabilized tamper-resistant dosage form

A tamper-resistant pharmaceutical dosage form comprising a pharmacologically active ingredient embedded in a prolonged release matrix, which comprises a prolonged release matrix material selected from the group consisting of nonionic acrylic polymers and waxy materials and which provides prolonged release of the pharmacologically active ingredient, resistance against solvent extraction, resistance against grinding, and resistance against dose-dumping in aqueous ethanol.

Tamper resistant and dose-dumping resistant pharmaceutical dosage form

A pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, wherein the dosage form contains a pharmacologically active ingredient (A); an inorganic salt (B); and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the inorganic salt (B) and the polyalkylene oxide (C) and wherein, under in vitro conditions, the release profile of the pharmacologically active ingredient (A) from the matrix comprises at least a time interval during which the release follows zero order kinetics.

Tamper resistant dosage form comprising inorganic salt

The invention relates to a tamper-resistant pharmaceutical dosage form comprising one or more particles, wherein each of said one or more particles

Tamper-resistant dosage form containing one or more particles

The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back side; wherein 

Hot-melt extruded pharmaceutical dosage form

A thermoformed, tamper-resistant pharmaceutical dosage form comprises: When the pharmacologically active ingredient is effective against pain, the pharmaceutical dosage form may be used in a method of treating pain. When the pharmacologically active ingredient has abuse potential, the pharmaceutical dosage form may be used in a method of reducing the incidence of the abuse of said pharmacologically active ingredient.

Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc

The invention relates to an oral pharmaceutical dosage form providing resistance against dose dumping in aqueous ethanol and comprising a pharmacologically active ingredient embedded in a matrix material,

Multiparticles safeguarded against ethanolic dose-dumping

A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

Tamper-resistant dosage form with immediate release and resistance against solvent extraction

The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength Bof at least 500 N in direction of extension Eand having a breaking strength Bof less than 500 N in direction of extension E.

Pharmaceutical dosage form

The invention relates to a pharmaceutical dosage form comprising

Growing community of inventors

Mönchengladbach, Germany

Lutz Barnscheid