Baxter International Inc.

Baxter Healthcare Sa

Lushan Zhou

William S Hurst

Gert Najdeni

Kent Alan Williams

Michael P Wehrli

Luis Ernesto Criales Escobar

Jessica Tam

Joseph Edward Bigalke

Karan Kerwell

Michael Imeobong Essien

A method of mixing a pharmaceutical solution including adding a gas into an interior compartment of a mix bag to form a headspace. The interior compartment of the mix bag includes a top portion and a bottom portion. The headspace adjacent to the top portion contains gas. The method includes adding a solvent into the mix bag, and establishing a bubble column in the interior compartment by activating a recirculation assembly. The recirculation assembly includes a connecting pathway operably coupled to a recirculation pump. A first end of the connecting pathway is coupled to a top gas recirculation port and a second end is coupled to a bottom gas recirculation port of the mix bag such that the recirculation pump draws the gas from the headspace and delivers the gas to the interior compartment via the bottom gas recirculation port. The method includes adding a solute into the mix bag.

Method of mixing a pharmaceutical solution and mixing system

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Ingleside, IL, United States of America

Lushan Zhou