Janssen Pharmaceutica Nv

Insilico Medicine IP Limited

Luoheng Qin

Qian Liu

Haibing Guo

Zhao-Kui Wan

Xin Cheng

Wing Shun Cheung

Yingtao Liu

Feng Ren

Jianping Wu

Jinxin Liu

The invention relates to new thienopyridinone compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and to their use in the treatment of diseases, e.g. cancer.

Thienopyridinone compounds

The disclosure provides for compounds and methods for modulating or inhibiting glutaminyl-peptide cyclotransferase-like protein (QPCTL). In one aspect, described herein are compounds of Formulas (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), and (IIbb), stereoisomer thereof, or salts or solvates thereof. Further provided herein are methods of treating a disease or a condition comprising administering a compound of Formula (I), (Ia), (Ib), (Iaa), (Iab), (Iba), (Ibb), (II), (IIa), (IIb), (IIaa) (IIab), (IIba), or (IIbb), a stereoisomer thereof, or a salt or solvate thereof.

Beta-lactam derivatives for the treatment of diseases

Described herein are KAT6A inhibitors of Formula (Ia) and pharmaceutical compositions comprising said inhibitors. The subject compounds of Formula (Ia) and compositions are useful for the treatment of a disease or disorder associated with KAT6A

Lysine acetyltransferase 6A (KAT6A) inhibitors and uses thereof

The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.

Small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof

Pyrazolopyridinone compounds, the pharmaceutical compositions comprising said compounds, and the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and their use in the treatment of diseases, e.g. cancer.

Pyrazolopyridinone compounds

The invention relates to new quinolinone compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds as FGFR (fibroblast growth factor receptor) inhibitors and to their use in the treatment of diseases, e.g. cancer.

Growing community of inventors

Shanghai, China

Luoheng Qin