Harbin Zhenbao Pharmaceutical Co., Ltd.

Eli Lilly and Company

Medshine Discovery Inc.

Honor Device Co., Ltd.

Lun Lu

Yong Wang

Shuhui Chen

Charles Z Ding

Lihong Hu

Jian Li

Wei Chen

Yang Zhang

Chun Sing Li

Wentao Wu

Bin Deng

Hua Zhu

Xiongbin Xu

Jean Marie Defauw

Scott Dale Holmstrom

Zhibo Zhang

Qingqing Lu

Yujuan Ma

Yong Cang

Xian Peng

Yufei Chen

A salt serving as an Akt inhibitor and a crystal thereof, specifically related to a salt of the compound of formula (I) and a crystal thereof. 

Salt serving as AKT inhibitor and crystal thereof

Provided is a dihydropyrazole azepine compound serving as an Akt inhibitor; specifically disclosed is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

Dihydropyrazole azepine compound serving as Akt inhibitor

The present invention relates to linkers, containing amide surrogates with a regular or a novel lysosomal enzymatic cleavable dipeptidic unit, to connect cytotoxic drugs to antibodies. The present invention also relates to ADCs (antibody-drug conjugates) derived from these amide surrogate linkers for the treatment of cancers.

Linkers and their application towards ADC

Provided are analgesic compounds, and salts thereof, of formula: (I) wherein A is: (A) Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided. 

Analgesic compounds, methods, and formulations

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Shanghai, China

Lun Lu