Univerzita Palackeho V Olomouci

Freie Universitat Berlin

Ustav Experimentalni Botaniky Av Cr, V.v.i.

Bioapex, S.r.o.

Institute of Experimental Botany, Academy of Sciences of the Czeck Republic

Institute of Experimental Botany, Academy of Sciences of the Czech Republic

Univerzita Palackego V Olomouci

Syngenta Participations Ag

Lukas Spichal

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

Jiri Voller

Lucie Plihalova

Lucie Szucova

Jiri Gruz

Ondrej Plihal

Frank J Massino

Jitka Ulrichova

Vaclav Mik

Petr Galuszka

Jitka Vostalova

Radoslav Koprna

Alena Rajnochova Svobodova

Tomas Werner

Thomas Schmulling

Jaroslav Nisler

Alena Kadlecova

Hana Vylicilova

Martin Hönig

Marketa Gemrotova

Jana Klaskova

Jitka Frebortova

Jana Bibova

Magdalena Bryksova

Ludek Frohlich

The invention relates to N,N-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.

9-(2-oxacycloalkyl)-9H-purine-2,6-diamine derivatives and their use for the treatment of skin disorders

Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA/UVB effects. These substances are particularly suitable as anti-senescent and UV-photoprotective component in cosmetic preparations, plant protection preparations and in preparations for the treatment/application of tissue cultures. 

Adenine derivatives and their use as UV-photoprotective agents

The invention relates to substituted 6-anilino-9-heterocyclylpurine derivatives of formula I wherein R denotes one to five substituents independently selected from the group hydrogen, halogen, hydroxy, amino, alkyloxy and alkyl group, R2 is selected from the group comprising amino, halogen, hydroxy, thio, and alkylthio group, Cyc is five- or six-membered heterocyclic ring containing one oxygen atom. The derivatives are useful for inhibition of plant stress.

Substituted 6-anilino-9-heterocyclylpurine derivatives for inhibition of plant stress

6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, whereinGly represents &#x3b2;-D-arabinofuranosyl or &#x3b2;-D-2'-deoxyribofuranosyl,Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use as antisenescent and UV protective compounds in animals.

6-aryl-9-glycosylpurines and use thereof

Substituted 1,2,3-thiadiazol-5yl-urea derivatives, their use as anti-senescence and anti-stress factors of plant cells, organs and the whole plant, and preparations containing these derivatives.

1,2,3-thiadiazol-5yl-urea derivatives, use thereof for regulating plant senescence and preparations containing these derivatives

The invention relates to 6-substituted 9-halogenalkyl purine derivatives of the general formula I wherein R6 is selected from the group comprising &#x2014;NH-furfuryl, &#x2014;NH-(4-hydroxy-3-methylbut-2-en-1-yl), &#x2014;NH-(3-methylbut-2-en-1-yl), &#x2014;NH-(4-hydroxy-3-methylbutyl), &#x2014;NH-(4-hydroxy-1,3-dimethylbut-2-en-1-yl), &#x2014;NH-(4-hydroxy-1,3-dimethylbutyl), &#x2014;NH-benzyl, &#x2014;NH-phenyl, wherein benzyl, furfuryl and phenyl can be unsubstituted or optionally substituted with 1 to 3 substituents selected from the group comprising hydroxy, halogen, methyl and methoxy, and R9 is selected from the group comprising C-Calkyl or C-Calkenyl wherein each of the groups is substituted with one or more halogen atoms, for use in the regulation of growth and development of plant cells, organs and/or whole plants. The invention also relates to preparations containing these derivatives and to novel to 6-substituted 9-halogenalkyl purines.

Use of 6-substituted 9-halogenalkyl purines for regulation of growth and development of whole plants, plant cells and plant organs; novel 6-substituted 9-halogenalkyl purines

The invention relates to substitution derivatives of N-benzyladenosine-5'-monophosphate of the general formula I, wherein (R)represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising Cto Calkyl, Cto Calkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. This invention also relates to methods of their preparation, their use as medicaments and in other biotechnological applications, and a therapeutic composition containing these derivatives.

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Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein Rand Rare as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.

6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions

The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives.

Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives

Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the following general formula are provided wherein R6 and R9 are as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for application to mammalian cells, and especially human skin cells, in order to improve the cosmetic appearance of the mammalian cells, especially human skin.

6,9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions

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Olomouc, Czechia

Lukas Spichal