Siemens Healthcare Gmbh

Siemens Aktiengesellschaft

Siemens Healthineers Ag

Earlybio Gmbh

Lukas Richter

Oliver Hayden

Matthias Ugele

Manfred Stanzel

Ali Kamen

Oliver Schmidt

Noha Youssry El-Zehiry

Gaby Marquardt

Bogdan Georgescu

Saikiran Rapaka

Anton Schick

Manfred Rührig

Daniela Seidel

Michael Johannes Helou

Uwe Philippi

Daniela Kühn

Markus Weniger

Mathias Reisbeck

Ann-Kathrin Reichenwallner

Karl-Philipp Matheis

Gabriele Hörnig

Gerald Warnat

Ann-Kathrin Wagner

An in-vitro method for determining a cell type of a white blood cell in a biological sample does so without labeling, wherein a microscopy apparatus images the cell, and physical parameters of the cell are ascertained from the image of the cell by an automated image analysis. The cell type of the white blood cell is determined on the basis of the physical parameters and on the basis of principal component analysis parameters (PCA parameters) , wherein the principal component analysis parameters comprise linear combinations of at least some of the physical parameters.

In-vitro method for determining a cell type of a white blood cell without labeling

The present invention relates to a method of detecting a possible infection of malaria in a patient using a digital optical microscope.

Specific malaria detection with digital holographic microscopy

A computer-implemented method for analyzing digital holographic microscopy (DHM) data for hematology applications includes receiving a DHM image acquired using a digital holographic microscopy system. The DHM image comprises depictions of one or more cell objects and background. A reference image is generated based on the DHM image. This reference image may then be used to reconstruct a fringe pattern in the DHM image into an optical depth map.

Auto-referencing in digital holographic microscopy reconstruction

The invention relates to a device for examining particles in a liquid to be examined, comprising a flow passage through which the liquid to be examined is moved. The flow passage has at least one inlet through which at least one sheath fluid flows into the flow passage such that the at least one sheath fluid forms at least one sheath flow in the flow passage. The device further comprises a wave generating device for piezoacoustically generating sound waves which propagate through the flow passage transversely to the flow direction of the liquid to be examined and form wave nodes on a monitoring plane such that particles to be examined of the liquid to be examined are moved onto the monitoring plane and accumulate thereon on the basis of the pressure effect of the sound waves in the transverse direction.

Flow cell for analyzing particles in a liquid to be examined

The present invention relates to an improved method for marker-free detection of a cell type of at least one cell in a medium using microfluidics and digital holographic microscopy, as well as a device, particular for carrying out the method.

High accuracy 5-part differential with digital holographic microscopy and untouched leukocytes from peripheral blood

A technique is presented for aligning, in a desired region within a flow chamber of a flow cell, a non-spherical biological entity carried in a sample. The flow chamber has a rectangular cross-section. A bottom flow input module, a top flow input module and a sample input module provide a viscoelastic first fluid, a second viscoelastic fluid, and the sample, respectively, to the flow chamber. The first and the second viscoelastic fluids laminarly flow along a bottom and a top wall of the flow chamber and the sample laminarly flows sandwiched between them. By controlling rate of flow of the first and/or the second viscoelastic fluids the sample flow, and thus the non-spherical biological entity, is focused in the desired region. A gradient of sheer within the sample flow set up due to the first and second viscoelastic fluids orients the non-spherical biological entity in the desired region.

Aligning a non-spherical biological entity in a sample flow using ambient viscoelastic fluid flows

The invention relates to a cartridge () for a magnetic flow cytometer, mainly extending in a x-y-plane, with an inlet () for injecting a sample () into the cartridge (), a blister () for a buffer solution () with magnetic markers to mark pregiven particles (') of the sample (), an outlet, and a fluid channel (), the fluid channel () comprising a first part that connects the inlet () with the blister () and a second part that connects the first part with the outlet, wherein the second part of the fluid channel () comprises an enrichment zone () with mechanical guiding structures to focus marked particles (&#x2032;) of the sample () in a predetermined subsection of the fluid channel () and a measuring zone () between the enrichment zone () and the outlet, the measuring zone () comprising a magnetic field sensor () in the predetermined subsection of the fluid channel () in order to provide simplified and accelerated means for measuring particles, in particular concentrations of particles, of a sample.

Cartridge for a magnetic flow cytometer, a magnetic flow cytometer, and method for analysing a sample with such a cartridge

An arrangement for modifying the local intensity of x-ray radiation includes an x-ray filter with a plurality of absorption chambers, which may be filled by a ferrofluid. The absorption chambers are stacked in the x-ray beam direction. The x-ray filter includes a plurality of storage containers in which the ferrofluid may be stored. Each of the absorption chambers is connected to a respective one of the storage containers. The absorption of the x-ray radiation is achieved as a result of individual absorption chambers being filled with the ferrofluid. By filling a different number of absorption chambers, the local intensity of the x-ray radiation may be modified easily, precisely and quickly.

Arrangement and method for modifying the local intensity of x-ray radiation

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Hirschaid, Germany

Lukas Richter