The University of Texas System

William Marsh Rice University

Arch Development Corporation

Pharmacia Corporation

Luka Milas

James Mitchell Tour

John Patrick McKearn

Dmitry Kosynkin

S Ward Casscells

Jaime L Masferrer

David J Grdina

Ashley Leonard

Jared L Hudson

Jeffrey N Myers

Valerie C Moore

Brandi Katherine Price

Kathy A Mason

Jodie L Conyers, Jr

Rebecca Lucente-Schultz

Zvonimir L Milas

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

Methods and pharmaceuticals for inhibiting or preventing metastasis formation in animals, including humans, having primary tumors, through the administration of phosphorothioates including their thiol and disulfide metabolites are disclosed. These compounds stimulate angiostatin levels, inhibit matrix metalloproteinases (MMPs), and stimulate manganese superoxidase dismutase (MnSOD). Phosphorothioates, of which amifostine is an example, can be administered as a combination therapy with traditional cancer therapies, including chemotherapy, radiotherapy, surgery, immunotherapy, hormone therapy and gene-therapy. Inhibition or prevention of metastasis by phosphorothioates is independent of tumor type, including adenocarcinomas and sarcomas.

Method for protection against tumor metastasis formation

The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of radiation therapy and a cyclooxygenase-2 inhibitor.

Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia

Growing community of inventors

Houston, TX, United States of America

Luka Milas