Amazonia Fitomedicamentos Ltda.

Luiz Francisco Pianowski

Joao B Calixto

Claudio Paulino Chaves

Paulo Cesar Leal

Amilcar Tanuri

Everardo Ferreira Telles

Joao Batista Calixto

Claudio P Chaves

João B Calixto

The present invention generally refers to an active fraction of an extract of the latex of plants from the family Euphorbiaceae in a polar solvent, as well as of one or more compounds contained therein, as well as the use of said fraction and/or said compounds, particularly in the treatment of cancer. The invention also refers to compositions comprising said active fraction and/or said compounds, as well as their use for the treatment of diseases concerning cell proliferation/angiogenesis, particularly cancer.

Active fraction of a polar solvent extract from the latex of euphorbiaceae plants

The present invention broadly relates to the use of certain ingenol derivatives as HIV reactivators of latent HIV virus in viral reservoirs. In another aspect, the present invention relates to an association comprising such ingenol derivatives and antiretroviral agents substantially active against actively replicating virus.

Ingenol derivatives in the reactivation of latent HIV

The present invention relates to new ingenol derivative compounds for inhibiting cancer cell viability and treating cancer. In other aspects, the invention relates to a pharmaceutical composition, a medicament, methods for treating cancer, and a dosage form.

Ingenol derivative compounds and methods useful for inhibiting cancer cell viability and treating cancer

The invention generally refers to pharmaceutical uses of lanosta-8,24-dien-3-ols, a family of tetracyclic terpenols, as anti-inflammatory, anticancerigenous and analgesic agents via the inhibition of the disordered activation of serine-threonine protein kinases, particularly PKC.

Growing community of inventors

Brangança Paulista, Brazil

Luiz Francisco Pianowski