Forschungszentrum Juelich Gmbh

Other

Forschungszentrum Julich Gmbh

Priavoid Gmbh

Luitgard Nagel-Steger

Dieter Willbold

Susanne Aileen Funke

Dirk Bartnik

Oleksander Brener

Oleksandr Brener

Antonia Nicole Klein

Gal Bitan

Thomas Schrader

Sharmistha Sinha

Julian Glueck

Daniel Frenzel

Lothar Gremer

Katrin Hochdörffer

Julia März-Berberich

The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.

D-enantiomeric peptides derived from D3 and use thereof

A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-&#x3b2; (A&#x3b2;) conformers, comprising the steps of: &#x2014;fractionating a sample including various A&#x3b2; conformers; &#x2014;immobilizing a biotinylated A&#x3b2; conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and &#x2014;deriving the binding behavior of an aggregate quality control probe to the desired A&#x3b2; conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.

Method for quantitative characterization of substances with regard to their properties of binding to amyloid-&#x3b2; (A&#x3b2;) conformers

A method for the quantitative characterization of amyloid and/or aggregated peptides and/or proteins in a sample, comprising:&#x2014;providing a sample, wherein the sample includes an amyloid and/or aggregated peptide and/or protein having at least one aggregate size and shape;&#x2014;adding an active ingredient to be analyzed to the sample solution;&#x2014;separating the amyloid and/or aggregated peptides and/or proteins are from one another according to their aggregate size and shape;&#x2014;optionally completely denaturing the amyloid and/or aggregated peptides and/or proteins of a particular fraction into monomer building blocks;&#x2014;determining the change in concentration of the peptide and/or protein building blocks in at least one fraction by comparison against control values without the active ingredient.

Method for the quantitative characterization of amyloid and/or aggregating peptides and/or proteins in a sample

The invention relates to novel multivalent polymeric amyloid-beta-binding substances composed of several interconnected substances which per se already have amyloid-beta-binding properties, and to the use of these substances, referred to hereinbelow as 'polymers', in particular in medicine.

Polymers containing multivalent amyloid-beta-binding D-peptides and their use

The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

Compounds for the treatment of diseases related to protein misfolding

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Langenfeld, Germany

Luitgard Nagel-Steger