Sigma-tau Industrie Farmaceutiche Riunite S.p.a.

Luisa Quadri

Luigi Bernardi

Piero Melloni

Patrizia Ferrari

Loredana Valentino

Mauro Gobbini

Mara Ferrandi

Giuseppe Bianchi

Marco Frigerio

Alberto Cerri

Marina Mauro

Nicoletta Almirante

Maria Pia Zappavigna

Gloria Padoani

Roberto Villa

Novel 17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl steroids of the general formula (I) ##STR1## where A, R.sup.1 and R.sup.2 are defined in the specification are disclosed. The compounds have cardiovascular activity. Pharmaceutical compositions containing compounds of formula (I) are also disclosed for the treatment of heart failure and hypertension.

17-hydroxyiminoalkyl and 17-hydroxyiminomethylalkenyl

17-Aryl -5.alpha.,14.beta.-androstane, androstene and androstadiene derivatives of formula (I): ##STR1## wherein the symbol --- represents a single or a double bond; when the double bond is not present in the 4 or 5 position, the hydrogen in position 5 has the .alpha. configuration; Y is oxygen or guanidinoimino, when --- in position 3 is a double bond; Y is hydroxy, OR.sup.2 or SR.sup.2, when in position 3 is a single bond and has an .alpha. or .beta. configuration; R is a substituted or unsubstituted aryl ring; and R.sup.1 is hydrogen, methyl, ethyl or n-propyl substituted by OH or NR.sup.4 R.sup.5.

17-aryl and 17-heterocyclyl-14.beta.-5.alpha.-androstane, androstene and

Cyclopentanperhydrophenantren-17.beta.-(3-furyl)-3-derivatives and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension, are disclosed.

Cyclopentanperhydrophenanthren-17.beta.-(3-furyl)-3-derivatives and

The present invention relates to a group of 17-(3-furyl)- and (4-pyridazinyl) 5.beta.,14.beta.-androstane derivatives, active on the cardiovascular system, to processes for their preparation and to pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension.

17-(3-furyl)-5.beta., 14.beta.-androstane derivatives active on the

Present invention relates to a group of 17-(4-pyridazinyl)-5.beta.,14.beta.-androstane derivates active on the cardiovascular system and to pharmaceutical compositions containing same.

17-(4-pyridazinyl) -5.beta., 14.beta.-androstane derivatives active on

17-aryl and heterocyclyl-5.beta.,14.beta.-androstane compounds having the formula (I) ##STR1## wherein R is an aryl ring or a saturated or unsaturated heterocyclic ring are active on the cardiovascular system and are useful in treating cardiovascular disorders.

17-Aryl and 17-heterocyclyl-5.beta.,14.beta.-androstane derivatives

17-Heterocyclyl-5.alpha.-14.beta.-androstane, androstene and androstadiene of formula (I): ##STR1## wherein: Y is oxygen or guanidinoimino, when a double bond exists at position 3; Y is hydroxy, OR.sup.2 or SR.sup.2, when a single bond exists at position 3; R is a saturated or unsaturated mono- or biheterocyclic ring, containing one or more heteroatoms selected from the group consisting of oxygen, sulfur, and nitrogen, unsubstituted or substituted by one or more of halogen, hydroxymethyl, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, sulfonamido, C.sub.1 -C.sub.6 lower alkyl or COR.sup.3 ; and R.sup.1 is hydrogen, methyl, ethyl or n-propyl substituted by OH or NR.sup.4 R.sup.5.

17-heterocyclyl-14beta-5alpha-androstane, androstene and androstadiene

14-Deoxy-14.alpha.-cardenolides 3.beta.-thioderivatives and pharmaceutical compositions comprising same for treating cardiovascular disorders, such as heart failure and hypertension, are disclosed.

Growing community of inventors

Cernusco, Italy

Luisa Quadri