Bracco Imaging S.p.a.

Luisa Poggi

Alessandro Maiocchi

Vittorio De Franciscis

Erika Reitano

Silvia Catuogno

Margherita Iaboni

Carla Lucia Esposito

Fulvio Uggeri

Silvio Aime

Massimo Visigalli

Giovanni Battista Giovenzana

Fabio Tedoldi

Mathilde H Lerche

Pernille Rose Jensen

Magnus Karlsson

Claudia Cabella

Luigi Miragoli

Sonia Colombo Serra

Lara Caminiti

Luca Venturi

Marco Crosetti

Silvia Nuzzo

Aldo Di Vito

The present invention provides nucleic acid aptamers binding to the Carbonic Anhydrase IX (CA-IX) enzyme, derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing CA-IX, or as therapeutic agents for prevention or treatment of CA-IX related diseases.

CA-IX aptamers and diagnostic and therapeutic uses thereof

The present invention provides nucleic acid aptamers binding to the Intercellular Adhesion Molecule-1 (ICAM-1), derivatives and conjugates thereof and their use as diagnostic tools, particularly for the imaging of organs and tissues expressing ICAM-1, or as therapeutic agents for prevention or treatment of ICAM-1-related diseases.

ICAM-1 aptamers, diagnostic and therapeutic uses thereof

The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.

Process for preparing hyperpolarized substrates and method for MRI

Growing community of inventors

Banchette d'Ivrea, Italy

Luisa Poggi