Andes Biotechnologies Global, Inc.

Andes Biotechnologies S.a.

Luis O Burzio Eriz

Veronica A Burzio Menendez

Jaime E Villegas Olavarria

Claudio E Villota Arcos

The invention provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating and preventing metastasis or relapse of a cancer in an individual previously treated for cancer with a therapy. The invention also provides oligonucleotides complementary to a non-coding chimeric mitochondrial RNA as well as compositions and kits comprising the same, and their use in treating a refractory cancer (e.g., a refractory HPV-associated cancer).

Antisense oligonucleotides for treatment of cancer stem cells

The invention provides methods for using the expression levels and subcellular localization of non-coding mitochondrial RNAs to select individuals or subpopulation of individuals for treatment with an anticancer therapy for multiple myeloma. Additional methods provided herein are useful for determining whether an individual in remission for multiple myeloma following successful treatment will be likely to suffer a relapse as well as to identify individuals who have suffered a relapse of multiple myeloma.

Growing community of inventors

Santiago, Chile

Luis O Burzio Eriz