University of Chile

Andes Biotechnologies S.a.

Novartis Ag

Andes Biotechnologies Global, Inc.

Luis O Burzio

Jaime E Villegas

Veronica A Burzio

Juan A Asenjo

Barbara A Andrews

Nathalie C Simard

Juan Pablo Acevedo

Pablo Valenzuela

Fernando Reyes

Huub Brouwers

Simon Jones

Steve Griffiths

Loreto Parra

Mauricio Salamanca

A novel family of human mitochondrial RNAs, referred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therefore, a novel approach for cancer therapy.

Markers for pre-cancer and cancer cells and the method to interfere with cell proliferation therein

Nucleic acid and corresponding amino acid sequences of a cold adapted subtilisin-like activity protein, insolated from antarctic marine origin, preferably from an Antarctic bacteria (sp) that can be used in a variety of industrial contexts and commercial purposes including laundry detergents, food processing, leather processing and skin care products. Nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the cold adapted subtilisin-like protein are also described.

Protein and DNA sequence encoding a cold adapted subtilisin-like activity

A method of preparing a cold adapted xylanase by use of recombinant DNA techniques. A nucleic acid and corresponding amino acid sequences of a cold adapted xylanase, isolated from antarctic marine origin, preferably from an Antarctic bacteria (sp.) are provided. These can be used in a variety of industrial contexts and for a variety of commercial purposes including more complete hydrolysis of lignocellulosic biomass into simple sugars that can then be fermented to products, such as liquid fuels and chemical feedstocks. The enzymes are also useful in the production methods of other industries, such as the animal feed, baking, and paper industries. Nucleic acids, corresponding amino acid sequences, constructs, expression vectors or integration vectors containing the DNA molecule, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides for producing and using the-derived cold adapted family GH10 xylanase-like protein are also described.

Protein and DNA sequence encoding a cold adapted xylanase

The present invention relates to a fish vaccine. More specifically the invention relates to a vaccine to protect salmon against infection by. The invention is based on or derived from the nucleic acid or amino acid sequence of antigens from. Nucleic acid and/or amino acid sequences may be used in the preparation of a vaccine to protect against infection by

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The present invention provides nucleic acid and corresponding amino acid sequences of two isoforms of cold adapted trypsin-like activity protein, insolated from antarctic marine origin, preferably from antarctic krill () that can be used in a variety of industrial contexts and commercial purposes including laundry detergents, food processing, drugs and skin care products. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the cold adapted trypsin-like protein.

Protein and nucleic acid sequence encoding a KRILL-derived cold adapted trypsin-like activity enzyme

Sequences from Piscirickettsia salmonis

Growing community of inventors

Santiago, Chile

Luis O Burzio