Massachusetts Institute of Technology

The Brigham and Women's Hospital, Inc.

Luis M Alvarez

Linda G Griffith

Richard Theodore Lee

Yadir Guerrero

Jaime Rivera

Linda Stockdale

The invention is directed to a composition comprising all or a portion of a beta-tricalcium phosphate (&#x3b2;-TCP) bound to all or a portion of a &#x3b2;-TCP binding peptide and methods of use thereof.

Tricalcium phosphate binding peptides and uses thereof

Provided herein are ligand dimers, compositions thereof, as well as methods of their use. The ligand dimers provided can comprise at least one ligand to a Her receptor and can be used to force dimerization of specific receptor pairs. The forced dimerization of specific receptor pairs can be used to control (e.g., promote or inhibit) signaling, and, therefore, the ligand dimers provided can also be used in various forms of treatment in which such signaling control is beneficial to a subject. It follows that methods for controlling signaling are provided as are various methods of treatment.

Compositions of and methods of using ligand dimers

Growing community of inventors

Cambridge, MA, United States of America

Luis M Alvarez