Centro De Ingenieria Genetica Y Biotechnologia

Luis Javier Cruz Ricondo

Gerardo Enrique Guillen Nieto

Enrique Iglesias Perez

Tania Carmenate Portilla

Eduardo Penton Arias

Maria De Jesus Leal Angulo

Antonieta Herrera Buch

Dagmara Pichardo Diaz

Verena Lucila Muzio Gonzalez

Julio Cesar Aguilar Rubido

Gloria Veliz Rios

Cirse Mesa Pardillo

Maydel Hechavarria Gay

Maylin Diaz Martinez

Juan Joel Madrazo Pi&ntilde;ol

The present invention is related to the field of medicine, particularly to the use of new adjuvant formulations with vaccine antigens. The technical objective pursued with this invention is, precisely, the development of formulations that are able to increase and/or modulate the immune response of the organism to vaccine antigens in the serum and the mucous lining. With this aim, a formulation was developed that contained as the main components the surface antigen of the hepatitis B virus and the acemannan in adequate proportions. As an extension of this result, formulations were developed in which a) HBsAg was used as the homologous or heterologous antigen carrier b) delivery systems of particulated antigens and c) soluble antigens, combined with the acemannan in specific proportions. The formulations of this invention are applicable in the pharmaceutical industry as vaccine formulations for human and veterinary use.

Immunopotentiating formulations for vaccinal use

Growing community of inventors

Havana, Cuba

Luis Javier Cruz Ricondo