The Mclean Hospital Corporation

Luis C Maas, Iii

Perry F Renshaw

Martin H Teicher

Carl M Anderson

Steven Bradley Lowen

Blaise deB Frederick

A method for treating attention deficit/hyperactivity disorder (ADHD) includes performing an objective ADHD behavioral assay for a patient, administering a drug to the patient at varying doses, and performing an fMRI on the patient for the varying drug doses to determine an optimal dosage for the patient. The method can further include performing a further objective ADHD behavioral assay after the drug administration.

Method for providing optimal drug dosage

A technique for computing a T2 relaxation time (RT) and for using the so computed T2 RT to provide an output which can aid in the detection of brain dysfunction including attention-deficit hyperactivity disorder (ADHD). The technique includes the step of obtaining T*1 matched axial images through a predetermined number of axial planes in a subject and obtaining one or more spin echo, echoplanar image sets, with TE incremented by a predetermined value in each consecutive image set through the same axial planes. The images are used to generate a map of T2 for each of the T*1 matched axial images and regions of interest (ROI) are identified in the matched axial images. Median pixel intensity values in the ROI are then used to compute a T2 relaxation time.

Method and apparatus for detecting mental disorders

Methods and systems for removing artifacts introduced by image registration

Methods and systems for estimating a correction angle that rotationally aligns a first polar centered image with a second polar centered image, wherein the first and second polar centered images includes values on a polar grid having evenly spaced polar angle coordinates for each of at least one radial distance coordinate, include the following steps: calculating a polar cross-power spectrum for the first and second polar centered images, the polar cross-power spectrum comprising a phase profile having at least polar angular frequency coordinates; and fitting a linear function of the angular frequency coordinate to the phase profile of the polar cross-power spectrum to determine the correction angle.

Methods and systems for registering image data

Registration of images includes rotational and translation correction. Rotational correction includes estimating a rotational-correction angle by polar K-space cross-correlation. K-space regridding is used to rotate an image by the estimated correction angle. Translational correction is obtained by K-space phase-plane conjugation.

Growing community of inventors

Brookline, MA, United States of America

Luis C Maas, Iii