Lung Biotechnology Pbc

Theradaptive, Inc.

Luis Alvarez

Derek Morris

Aman Kaur

Mohammadali Safavieh

Daniel Backman

Pingyong Xu

David W Stewart

Laurent Angibaud

Barbara Nsiah

Hyeon Park

Todd Heil

Iman Yazdi

Greg Hurst

Rebecca Duffy

Masoud Modaresifar

Jamie King

An additive manufacturing device includes an output device and a controller. The output device is configured to receive at least one material to generate a component. The controller includes one or more processors configured to receive a model including a plurality of pixels representing the component, identify at least one pixel of the plurality of pixels corresponding to a first surface of the component, modify the model to adjust an exposure corresponding to the at least one pixel based on a target exposure, and control operation of the output device to cause the output device to generate the component based on the modified model.

Systems and methods for three-dimensional printing and products produced thereby

Provided herein are polypeptides comprising a therapeutic targeted for delivery to an organ or tissue, and uses thereof.

Compositions and methods for targeted therapeutic delivery to bone

A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold; and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.

Two-phase 3D printing methods of forming biocompatible structures with immiscible liquids

Provided herein are methods which alter the mechanical and biological properties of polymeric materials. Also provided are compositions comprising the polymeric materials having said properties.

Modified 3D-printed objects and their uses

Provided herein are polypeptides that include one or more &#x3b2;-tricalcium phosphate (&#x3b2;TCP)-binding sequence(s) and uses thereof.

Polypeptides including a beta-tricalcium phosphate-binding sequence and uses thereof

A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm(Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

Material and method for producing cell receiving scaffold

Provided herein are beta-TCP binding sequences and chimeric polypeptides that include one or more beta-TCP binding sequences and a mammalian growth factor, compositions comprising any of these chimeric polypeptides (and optionally, beta-TCP), and methods of promoting bone or cartilage formulation, methods of replacing and/or repairing bone or cartilage, and methods of treating a bone fraction or bone loss that include administration of any of these compositions.

Growing community of inventors

Lexington, MA, United States of America

Luis Alvarez