Max-Planck-Gesellschaft Zur F&#xf6;rderung Der Wissenschaften E. V.

U3 Pharma Ag

Luis A Pardo

Mike Rothe

Esther Zwick-Wallasch

Walter Stühmer

Hendrik Knötgen

David Gómez-Varela

Kerstin Dehne

The present invention relates to a particularly advantageous antibody, antibody fragment or derivative thereof, which specifically binds to/interacts with at least one epitope of the extracellular or intracellular domain or the mammalian EAG1 ion channel and to nucleic acid molecules encoding these anti-EAG1 antibodies, antibody fragments or derivatives and to vectors comprising such nucleic acid molecules. The invention additionally relates to methods for the preparation of such anti-EAG1 antibodies, antibody fragments or derivatives thereof, pharmaceutical compositions comprising these antibodies, antibody fragments or derivatives, and methods of using the antibodies, antibody fragments or derivatives or the compositions for a variety of purposes, such as diagnosing disease, treating disease, assessing for the presence of EAG1-expressing cells, or blocking EAG1 function in cells.

Antibodies directed to the mammalian EAG1 ion channel protein

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Göttingen, Germany

Luis A Pardo