Children's Medical Center Corporation

Luigi Warren

Derrick J Rossi

Described herein are synthetic, modified RNAs for changing the phenotype of a cell, such as expressing a polypeptide or altering the developmental potential. Accordingly, provided herein are compositions, methods, and kits comprising synthetic, modified RNAs for changing the phenotype of a cell or cells. These methods, compositions, and kits comprising synthetic, modified RNAs can be used either to express a desired protein in a cell or tissue, or to change the differentiated phenotype of a cell to that of another, desired cell type.

Mammalian somatic cell with modified RNA encoding reprogramming factors

Isolated mammalian somatic cells containing modified RNA encoding OCT4, SOX2, and KLF4

Sustained polypeptide expression from synthetic, modified RNAs and uses thereof

Induced pluripotent stem cells with synthetic modified RNAs

Kits comprising linear DNAs for sustained polypeptide expression using synthetic, modified RNAs

Compositions, kits, and methods for making induced pluripotent stem cells using synthetic modified RNAs

Kit for making induced pluripotent stem cells using modified RNAs

Growing community of inventors

Boston, MA, United States of America

Luigi Warren