Laboratori Guidotti S.p.a.

Luigi Turbanti

Guido Cerbai

Giorgio Garzelli

Marco Criscuoli

The amides of cyclomethylen-1,2-bicarboxylic acids having the formula: ##STR1## wherein A represents ##STR2## R.sup.1 represents --H, --CH.sub.3, --CH.sub.2 --CH.sub.3, --CH(CH.sub.3).sub.2, ##STR3## R.sup.2 represents --H, CH.sub.3, --CH.sub.2 --CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 --CH.sub.2 --CH.sub.3, --CH.sub.2 --CH(CH.sub.3).sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.3, --CH.sub.2 --C.sub.6 H.sub.5, --C.sub.6 --H.sub.5 ;

Amides of cyclomethylen-1,2-bicarboxylic acids having therapeutical

For the preparation of 3-hydroxy-3-methyl-glutaric acid a process is disclosed based on the direct oxidation with nitric acid of 3-methyl-1,3,5-pentanetriol.

Process for preparation of 3-hydroxy-3-methyl-glutaric acid

The esters of N-alkyl-nortropines with phenyl-cyclohexen-carboxylic and phenyl-cyclohexen-acetic acids and their quaternary ammonium derivatives with alkyl halides and alkyl sulphates having general formula: ##STR1## whereas R'=-, --H, --CH.sub.3, --CH.sub.2 --CH.sub.3, --CH.sub.2 --CH.sub.2 --CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2 --CH.sub.2 --CH.sub.2 --CH.sub.3, --CH.sub.2 CH--(CH.sub.3).sub.2 X.sup.- =Cl, Br, I, CH.sub.3 SO.sub.4 show anti-bronchospastic activity. The invention relates also to the processes for their preparation and to the pharmaceutical compositions containing them.

Growing community of inventors

Pisa, Italy

Luigi Turbanti