Glaxo Group Limited

Luigi Piero Stasi

Colin Philip Leslie

Jessica Tibasco

Domenica Antonia Pizzi

Alessandro Falchi

Matteo Biagetti

Marilisa Rinaldi

Giancarlo Merlo

Simon Edward Ward

Barbara Bertani

Markus Bergauer

Steven Mark Bromidge

Antonio Kuok Keong Vong

Disclosed are methods for the preparation of compounds of formula (I): wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description.

Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors

Disclosed are methods for use of compounds of formula (I) in combination with other active substances in the treatment of CNS disorders such as depression or anxiety. wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description.

Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided: wherein R, m, X, R, n, W, p, Y, Z, R, R, Rand q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.

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Verona, Italy

Luigi Piero Stasi