Materias S.r.l.

C.r.f. Societa Consortile Per Azioni

Altergon Sa

Gelesis LLC

Stmicroelectronics S.r.l.

Sca Hygiene Products Ab

M.u.r.s.t. (Italian Ministry for Universities and Scientific and

Nano Active Film S.r.l.

Università Degli Studi Di Napoli Federico Ii

Sanidrink S.r.l.

Luigi Nicolais

Alessandro Sannino

Luigi Ambrosio

Gianfranco Carotenuto

Luca De Stefano

Christian Demitri

Brunetto Martorana

Aniello Anastasio

Federico Capuano

Gianluca Neglia

Gianna Palmieri

Marco Balestrieri

Lanfranco Callegaro

Piero Perlo

Salvatore Leonardi

Valeria Casuscelli

Pietro Perlo

Gaetano Guerra

Raffaele Vecchione

Fabrizio Porro

Maria Viviana Volpe

Paola Rizzo

Rita Patrizia Aquino

Principia Dardano

Antonietta Cozzolino

Fabrizio Errichiello

Ernesto Di Maio

Aniello Cammarano

Assunta Borzacchiello

Nicola Solimando

Maurizio Pagliuca

Christophe Daniel

Paolo Antonio Netti

Ilaria Rea

Gianluigi De Falco

Paola Russo

Pasquale Del Gaudio

Floriana Esposito

Guiseppe Mensitieri

Andrea D'ANNA

Mario Commodo

Patrizia Minutolo

Antonino Squillace

Tubular conduits are provided which have an outer surface and/or an inner surface functionalized with at least one antimicrobial peptide having the sequence XXWVXIWVXX, wherein X, X, X, Xand Xare independently selected from K and R and wherein each amino acid is independently in the D or L configuration, or a salt or solvate thereof. The tubular conduits are preferably made of biodegradable polymeric material. The functionalization of the tubular conduits with the at least one antimicrobial peptide prevents contamination caused by Gram negative bacteria, Gram positive bacteria, fungi, yeasts and/or viruses.

Antimicrobial tubular conduits

A process for manufacturing products made of foamed polymeric material, comprising the following steps: generating, via software, a virtual model (M) of a product to be manufactured in a solid foamable polymeric material; performing a topological optimization via software of the virtual model (M) in order to obtain an optimized virtual model (MO) with areas of differentiated relative density; preparing the foamable polymeric material and inserting it in a mold (); solubilizing, under pressure, at least one foaming agent in the foamable polymeric material placed in the mold () with a pressure profile of the foaming agent variable over time and/or space as a function of the topological optimization; releasing the pressure in order to obtain a product (S) made of foamed polymeric material provided with the above-mentioned areas of differentiated relative density; removing the product (S) made of foamed polymeric material from the mold ().

Process for making products of multi-gradient foamed polymeric material

The present invention relates to compositions based on: (a) a glycosaminoglycan or mixtures thereof; (b) one or more tocopherols, tocotrienols and mixtures thereof; and (c) a selected stabilizer. The composition is a solution, with the agents not chemically bound with each other. The component (a) can be hyaluronic acid (HA) or a salt thereof; the component (b) can be a polyether clathrate a cyclodextrin, or a combination of a fatty acid with an emulsifier; the component (c) can be α-tocopherols, β-tocopherols, γ-tocopherols, δ-tocopherols; α-tocotrienols, β-tocotrienols, γ-tocotrienols, δ-tocotrienols. Preferably component (c) is vitamin E. The agents strongly cooperate to provide enhanced and more stable viscoelastic properties, resulting in a product with higher resistance to thermal treatments like e.g. heat-sterilization, autoclaving, etc. The present compositions, optionally loaded with pharmaceutically and/or cosmetically active agents, are advantageously used in medical or cosmetic methods.

Synergistically cooperative compositions useful for soft tissue augmentation, drug delivery and related fields

The present invention relates to the use of at least one peptide having sequence VRLIVAVRIWRR, VRLIVAVRIKRR, VRLIVKVRIWRR, VRLIVKVRIKRR (SEQ ID NO: 1, SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4), as a bactericidal antimicrobial agent against

Antimicrobial peptides

The present invention regards yarns comprising at least 1% by weight of fibre of a syndiotactic polystyrene containing a co-crystalline phase comprising at least one active guest compound, textiles comprising the aforementioned yarns and methods for preparing the same.

Active yarns and textiles for the stabilization and controlled release of active compounds

The object of the present invention is a device () for the transdermal delivery of active molecules. The device () comprises a support element () and a plurality of micro-needles () that protrude from a first surface of the support element (), the support element () and the micro-needles () being both permeable to the active molecules. The device () further comprises a porous membrane () configured to be loaded with said active molecules, which lies on a second surface of the support element (). Characteristically, the porous membrane () is configured to behave, from an optical viewpoint, as a Bragg mirror. Further objects of the present invention are the following uses of the device (): for monitoring the release and/or the decay of the active molecules, for the optical control of the release of the active molecules and for the thermal control of the release of the active molecules. Lastly, an object of the present invention is the method for producing the device () for transdermal delivery of active molecules.

Device for transdermal delivery of active molecules, uses of the device and methods for producing the device and its components

A composition in powder form comprising alginic acid or sodium alginate, -pectin and chitosan, wherein the % by weight of the polysaccharides is at least 20% with respect to the total weight of the powder, the process for preparing the powder and its use in the treatment of cutaneous wounds and in the sector of food preservation are described.

In situ gelifying powder

The present invention relates to the use of at least one peptide having sequence VRLIVXVRIXRR (SEQ ID NO: 1, SEQ ID NO 2, SEQ ID NO 3, SEQ ID NO 4), wherein X1 is selected from A or K and Xis selected from W and K, as a bactericidal antimicrobial agent against

Antimicrobial peptides against

The invention relates to a method for the preparation of a polymer hydrogel, comprising cross-linking a precursor comprising a hydrophilic polymer optionally in combination with a second hydrophilic polymer, using a polycarboxylic acid as the cross-linking agent. The invention further concerns the polymer hydrogel obtainable by the method of the invention and the use thereof in a number of different applications.

Polymer hydrogels and methods of preparation thereof

The present invention relates to a process for the preparation of a composite polymeric material containing nanometric inorganic inclusions comprising the steps of: mixing a polymer with a thermolytic precursor to provide a homogeneous dispersion of said at least one precursor and of said at least one polymer; subjecting said homogeneous dispersion to heating to provide a molten polymer and thermolytic fission of the precursor, generating the inclusions dispersed in the molten polymer.

Process for the preparation of a composite polymeric material

The present invention relates to a process for the production of continuous silver wires having micrometric or sub-micrometric diameter comprising a step of thermal decomposition of silver dodecyl-mercaptide in the presence of metallic aluminum.

Process for the production of silver filaments having micrometric or sub-micrometric diameter and product thereof

The method for the production of polymer/metal or metal sulphide composites comprises the stages of: preparing a dispersion of a metal mercaptide in a polymer, the metal of the mercaptide being selected from the group comprising the transition metals and earth metals, and heating the said dispersion so as to cause thermal decomposition of the mercaptide and obtain the corresponding metal or metal sulphide in the form of inclusions in a polymer matrix.

Method of production of polymer/metal or metal sulphide composites, which uses metal mercaptides

A superabsorbent polysaccharide can be obtained by crosslinking a polysaccharide or derivative thereof with at least 1% by weight of a flexible spacer having a chain length of at least 9 chain atoms and having terminal activated coupling groups. The flexible spacer may comprise a polyalkyleneglycol with a molecular weight from about 400 to 10,000. The coupling groups may be provided by divinyl sulphone units.

Polysaccharide-based superabsorbent film

Use of hydrogels to fix bone replacements

Growing community of inventors

Ercolano, Italy

Luigi Nicolais