Cell Genesys, Inc.

Gbp Ip, LLC

Luigi Naldini

Deborah A Farson

Thomas L Dull

Rochelle Witt

Anatoly Bukovsky

Ryan McGuinness

Lentiviral vectors modified at the 5' LTR or both the 5&#x2032; and 3&#x2032; LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.

Method and means for producing high titer, safe recombinant lentivirus vectors

Lentiviral vectors modified at the 5' LTR or both the 5&#x2032; and 3&#x2032; LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production. The vectors can contain inducible or conditional promoters.

Method and means for producing high titer, safe, recombinant lentivirus vectors

A method for selecting packaging cells that express high levels of gag/pol is provided.

Selection system for generating efficient packaging cells for lentiviral vectors

Lentiviral vectors modified at the 5&prime; LTR or both the 5&prime; and 3&prime; LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.

Lentiviral vectors modified at the 5' LTR or both the 5' and 3' LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus production.

Growing community of inventors

San Carlos, CA, United States of America

Luigi Naldini