Brown University

Fondazione Istituto Italiano Di Tecnologia

Fremslife S.r.l.

Luigi Miracoli

Patrick Aebischer

Pierre M Galletti

Franco Bertora

Rosalia Bertorelli

George Panol

Athanassia Athanassiou

Michele Palermo

Maria Summa

Marco Contardi

Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secreting an active agent, which is preferably adapted for implantation within the body of the subject and further includes at least one semipermeable membrane, whereby the transplanted cells can be nourished by nutrients transported across the membrane while at the same time protected from immunological, bacterial, and viral assault. The systems further include a pumping means, which can be implantable or extracorporeal, for drawing a body fluid from the subject into the cell reservoir and for actively transporting the secreted biological factors from the cell reservoir to a selected region of the subject.

Implantable delivery system for biological factors

Growing community of inventors

Genoa, Italy

Luigi Miracoli