Mediolanum Farmaceutici

Euticals Spa

Luigi Filocamo

Mario Brufani

Stefano Maiorana

Pier G Pagella

Enrico Ferrari

Sperandina Lappa

Maria C Cesta

Maria Alessandra Alisi

Barbara Garofalo

Donata Marchesini

Adriana Caterina Maggi

Luisa Maria Migneco

Rinaldo Marini Bettolo

Paolo Maria Farina

Gianluca Gostoli

Roberta Joudioux

Gillian Ashcroft

Francesca Ceccacci

The invention relates to 17&#x3b1;-(5-hydroxy-C-hydrocarbyl)-1,3,5(10)-estratrien-3,17&#x3b2;-diol derivatives having cicatrising activity, preferably for topical use on wounds, without significant systemic effects, and to pharmaceutical compositions containing them. In particular, the invention relates to estradiol 17&#x3b1;-(5-hydroxypentyn-1-yl)derivatives and 3-esters, 5'-esters and 3,5&#x2032;-diesters thereof and to a process for the preparation thereof by reaction of 3-OR-protected estrone with an alkali metal derivative of OR-protected 5-pentynol, followed by 3-, 5-&#x2032; or 3,5&#x2032;-esterif&#xca;cation.

17-alpha-substituted derivatives of estradiol with wound-healing activity

Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase C of general formula (I) ##STR1## wherein X and R have the meanings specified in the description, suitable for preparing pharmaceutical compositions for the treatment of tumoral, thrombotic and inflammatory type pathologies.

Phosphatidylinositol analogues, inhibitors of phosphatidylinositol

Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting of ##STR2## and n, R1, R2, R3, and R4 are as defined in the text.

Aminoalkylcarbamic esters of eseroline suitable for use as

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Rome, Italy

Luigi Filocamo