Glaxosmithkline Biologicals Sa

Novartis Ag

Luigi Fiaschi

Fabio Bagnoli

Maria Scarselli

Guido Grandi

Nathalie Norais

Ravi Pratap Narayan Mishra

Massimiliano Biagini

Ravi Mishra

Mutant protein A of(SpA) with decreased affinity for the Fc&#x3b3; portion of human IgG is provided.

Mutant staphylococcal antigens

An effectivevaccine may require several antigenic components, and so various combinations ofantigens are identified for use in immunisation. These polypeptides may optionally be used in combination withsaccharides.

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An effectivevaccine may require several antigenic components, and so various combinations ofantigens are identified for use in immunization. These polypeptides may optionally be used in combination withsaccharides.

Hla polypeptides having various deletions, insertions, and/or mutations which are useful for immunization are provided herein. Also provided herein are Hla heptamers which are non-haemolytic. Additionally, an effectivevaccine may require several antigenic components, and so various combinations ofantigens, including Hla polypeptides having deletions, insertions, and/or mutations, are identified for use in immunization. These polypeptides may optionally be used in combination withsaccharides.

Growing community of inventors

Sovicille, Italy

Luigi Fiaschi