Farmitalia Carlo Erba S.r.l.

Luigi Donno

Giuseppe Cassinelli

A compound of formula (I): ##STR1## wherein: R.sub.1 is a hydroxy group or an amino group optionally substituted with a C.sub.1 -C.sub.4 alkyl or phenyl-(C.sub.1 -C.sub.4) alkyl group, R.sub.2 is hydrogen or a hydroxy group, R.sub.3 is hydrogen or chlorine, R.sub.4 is hydrogen or a hydroxy or amino group, R.sub.5 is hydrogen or a hydroxy group, and R.sub.6 is hydrogen or a hydroxy group, or a non-toxic acid addition salt thereof, is useful in the parenteral treatment of visceral leishmaniasis or malaria, and a synergistic composition comprising a compound of formula (I) or a non-toxic acid addition salt thereof and sodium stibogluconate is useful in the treatment of visceral leishmaniasis.

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Milan, Italy

Luigi Donno