Gruppo Lepetit

Vicuron Pharmaceuticals Inc.

Luigi Colombo

Enrico Selva

Maurizio Denaro

Sergio Stella

Nicoletta Montanini

Francis J LeMonnier

Martin Stogniew

Romeo Ciabatti

The invention provides methods and compositions for treatment of bacterial infections. The composition may be a combination of factors, which include A, A, B, B, C, C, isoB, and MAG, in the presence of low level solvent. Methods of the invention include administration of dalbavancin formulations for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimens include multiple dose administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection. Dosing regimens for renal patients are also included.

Dalbavancin compositions for treatment of bacterial infections

The present invention is directed to new antibiotic substances denominated antibiotics GE 37468 A, B and C, their addition salts with bases, the pharmaceutical compositions thereof and their use as medicaments, particularly in the treatment of infectious diseases involving microorganisms susceptible to them. The compounds of the invention are also active as growth promotant agents in animals, such as poultry, swine, ruminants, etc.

Antibiotics GE 37468 A, B and C

The present invention is directed to a new antibiotic substance denominated antibiotic GE 2270 factor C.sub.2a, the addition salts thereof, the pharmaceutical compositions thereof and its use as medicament, particularly in the treatment of infectious diseases involving microorganisms susceptible to it and its use as animal growth promoter.

Antibiotic GE 2270 factors C.sub.2a

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Malnate, Italy

Luigi Colombo