Universitè De Genève

University of Geneva

Luigi Bonacina

Jean-Pierre Wolf

Andre Liani

Ueli Schibler

Gustavo Alexandre Subtil Sousa

Camille Saini

Denis Kiselev

André Liani

This invention concerns the field of sample identification, in particular a method and apparatuses for identifying or discriminating biological species from non biological species, both as individual particles and as components of a composition, by pump-probe fluorescence spectroscopy for time-resolved detection or imaging. The method uses the finding that the UV-induced fluorescence of biological molecules is varied, in particular is depleted, by the addition of visible radiation, whereas this does not occur with non-biological organic molecules. The invention discriminates the fluorescence signals of bio and non-bio particles or species using a differential approach, i.e. the comparison. of the total fluorescence recorded with and without additional visible radiation. This allows to discriminate biological particles comprising aromatic amino-acids (AA), like peptides, proteins, bacteria, viruses, pollens, spores, etc., from non-biological particles, like aromatic (AH) or polyaromatic hydrocarbons (PAH), carbonaceous aerosols, soot, etc.

Method and apparatus for detecting and discriminating biological from non-biological species

Apparatus for real-time in vivo bioluminescence monitoring in a conscious small animal, comprising a light-tight enclosure () with a base (), side wall () and cover () configured for housing the small animal such that it may move freely, a bioluminescence detector system () comprising a light detector () for detecting the light emitted by said small animal connected to a data processing system, and a life-sustaining system () configured for maintaining the small animal alive for a prolonged period of time spanning from a few days to a few weeks.

In vivo bioluminescence monitoring apparatus

A measurement device and method for the detection of airborne particles. The device includes a nozzle designed to produce a laminar flow of air with a flow path beyond the nozzle, a first laser and a second laser being positioned for emitting time-amplitude modulated laser light with intersecting laser beams with a laser beam intersection region in a region of the air flow path, and two photodetectors positioned for the detection of laser light scattered in the laser beam intersection region by airborne particles contained in the laminar air flow. The lasers are designed for emission of time-amplitude modulated laser light of identical laser emission wavelength, and the photodetectors are positioned and designed each for the detection of scattered laser light from both lasers.

Measurement device and method for detection of airborne particles

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Lausanne, Switzerland

Luigi Bonacina