Adare Pharmaceuticals S.r.l.

Societe Des Produits Nestle S.a.

Adare Pharmaceuticals, Inc.

Aptalis Pharma Limited

Allergan Pharmaceuticals International Limited

Laboratorio Chimico Internazionale S.p.a.

Luigi Boltri

Flavio Fabiani

Luigi Giovanni Mapelli

Paolo Gatti

Mauro Serratoni

Roberto Cassanmagnago

Christian Stollberg

Giovanni Ortenzi

Giuseppe De Franza

Danilo Clementi

Gopi M Venkatesh

Jin-Wang Lai

Antonio Nardi

Annibale Salvi

Stephen Perrett

Flavio Villani

Paolo Magri'

Ruth Thieroff-Ekerdt

Luigi Ghidorsi

Italo Colombo

Letizia Ubliglia

Vincenza Pironti

Giancarla Bianchi

Devrim Eren

Letizia Ubiglia

Ruth Ekerdt

Robert Becker

Paola Arzuffi

Luigi Mapelli

Flavio Flabiani

Emanuela Ronda

The present invention is directed to a pharmaceutical composition or dosage form having a stable, low (diluted) digestive enzyme content comprising at least one digestive enzyme and at least one carrier, or a dosage form thereof. The invention is also directed to a process of preparation of the composition or the dosage form. In addition the invention is directed to the treatment and prevention of disorders or conditions associated with a digestive enzyme deficiency in a patient in need thereof, comprising administering to said patient a pharmaceutically acceptable amount of the composition having a stable low digestive enzyme content or dosage form thereof.

Stable low digestive enzyme content formulation

The present invention is directed to a digestive enzyme composition comprising an enterically coated digestive enzyme product, administrable nutritional medium, and a pharmaceutically acceptable low viscosity oily ingredient. The process for the preparation of the digestive enzyme composition comprises adding an enterically coated digestive enzyme product to a administrable nutritional medium and pharmaceutically acceptable low viscosity oily ingredient. The invention further provides a method for treating a patient suffering from exocrine pancreatic insufficiency related condition comprising administering to the patient a therapeutically effective dose of the digestive enzyme composition by means of a feeding tube.

Digestive enzyme composition suitable for enteral administration

The present invention is directed to pharmaceutical compositions and dosage forms comprising TPR beads, wherein said TPR beads comprise a solid dispersion of at least one active pharmaceutical ingredient in at least one solubility-enhancing polymer, and a TPR coating comprising a water insoluble polymer and an enteric polymer, wherein the active pharmaceutical ingredient comprises a weakly basic active pharmaceutical ingredient having a solubility of not more than 100 &#x3bc;g/mL at pH 6.8.

Drug delivery systems comprising solid solutions of weakly basic drugs

The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.

Fexofenadine microcapsules and compositions containing them

The present invention provides a microcapsule pharmaceutical composition of at least a bisquinoline drug. said microcapsule comprises a drug core of a pharmaceutically effective amount of a bisquinoline drug and a polymeric coating over the core. This microcapsule pharmaceutical composition has desirable pharmaceutical properties, including taste masking effect and a high stability.

Piperaquine microcapsules and compositions containing them

Lipoic acid pellets are described, obtained from inert cores externally coated with lipoic acid. The so obtained active cores are coated with a first layer of insulating polymeric material and then with a polymeric coat that is insoluble at the gastric pH. Pellet are then formulated pharmaceutically, for instance in jelly capsules or controlled release capsules or as oral suspensions, dispersible powders, sachets, etc.

Lipoic acid pellets

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Agrate Brianza, Italy

Luigi Boltri