Rotta Research Laboratorium

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Rottapharm Spa

Rotta Research Laboratories S.p.a.

Rotta Research Laborarorium S.p.a.

Luigi A Rovati

Francesco Makovec

Walter Peris

Lucio C Rovati

Paolo Senin

Rolando Chiste

Rolando Chiste'

Gunter Cordes

Ivo Setnikar

Rafat R Ansari

Wilfried Fischer

Giovanni Staurenghi

Pierluigi Casula

Formulation for oral administration, in the form of tablets or of powder for extemporaneous use, able to exert a beneficial effect on the cardiovascular system and having eulipidaemic activity, cholesterol-lowering and triglyceride-lowering activity, antioxidant activity, and a protective action on the vasal endothelium, comprising berberine in combination with a policosanol and/or red yeast and preferably containing an antioxidant, such as astaxanthin and/or folic acid.

Formulation for oral administration with beneficial effects on the cardiovascular system

In a laser eye treatment apparatus, a probe light source generates a secondary emitted light emanating from a treatment area of retinal tissue that is irradiated by a treatment light source. An optical detector detects the secondary emitted light. A processor statistically analyzes the secondary emitted light to determine a temperature of the treatment area of retinal tissue.

Monitoring of retinal temperature during laser therapy

An apparatus ( ) for determining a diagnostic glucose level in a human subject includes a light source ( ) that produces collimated light at a selected wavelength. The collimated light is arranged such that it passes through a portion of an eye ( ) of the subject and reflects off an eye lens ( ) at a selected angle (&thgr; ) as reflected light. A polarization analyzer ( ) measures a polarization of the reflected light that exits the eye ( ). A path length processor ( ) determines an optical path length (L ) of the reflected light within an aqueous humor ( ) of the eye ( ). A glucose level processor ( ) computes a glucose concentration based on the measured polarization and the determined optical path length (L ).

Method and apparatus for the non-invasive measurement of blood glucose levels in humans

Preparation with an acrylic-based, adhesive copolymeric matrix for the

Anthranilic acid diamides derivatives, their preparation and

Quinazoline-4-amino-2-(piperidine-1-yl-4-substituted) derivatives having

Polyamidic acid derivatives with antigastrin activity, a method for

Aromatic acid diamides with antigastrin activity, a method for their

The invention is directed to glutamic acid and aspartic acid derivatives represented by formula (I): ##STR1## wherein R.sub.1 is selected from the group consisting of unsubstituted, mono- or di-substituted phenyl groups, unsubstituted, mono- or di-substituted phenylamino groups, a 2(beta)naphthyl group, and heterocyclic, monocyclic and dicyclic groups; R.sub.2 is selected from heterocyclic spiro groups, aminoalkyladamantyl groups, alkylamino groups, C.sub.4 -C.sub.10 cycloalkylamino groups and dicyclic amino groups (condensed); R.sub.3 is H, CH.sub.3 or C.sub.2 H.sub.5 ; A is a bond or a linear or branched alkylene group having from 1 to 4 carbon atoms; W is a tertiary amino group or a heterocyclic group; and r is 1 or 2. The compounds have a potent antagonistic effect on gastrin and cholecystokinin and can be used to treat diseases which are linked to imbalances in the physiological levels of gastrin, cholecystokinin or other biologically active polypeptides related thereto.

Basic derivatives of glutamic acid and aspartic acid as gastrin or

Derivatives of glutamic and aspartic acids, a method of preparing them,

There are described optically active derivatives of (R) 5-pentylamino-5-oxopentanoic acid and their pharmaceutically acceptable salts, having antagonistic activity towards cholecystokinin, and with the formula: ##STR1## in which R.sub.1 is selected from the groups 2-naphthyl, 3,4-dichlorophenyl and 3,4-dimethylphenyl and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 carbon atoms, and in which the substituents on the central chiral group (marked with an asterisk in Formula (I)), have the R (rectus) conformation.

Optically-active derivatives of (R) 5-pentylamino-5-oxopentanoic acid

Amidic derivatives of glutamic, aspartic and 2-amino adipic acids, a

There are described optically active derivatives (R) 5-pentylamino-5-oxopentanoic acid and their pharmaceutically acceptable salts, having antagonistic activity towards cholecystokinin, and with the formula: ##STR1## in which R.sub.1 is selected from the groups 2-naphthyl, 3,4-dichlorobenzoyl and 3,4-dimethylbenzoyl and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 carbon atoms, and in which the substituents on the central chiral group (marked with an asterisk in Formula (I)), have the R (rectus) conformation.

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Monza, Italy

Luigi A Rovati