Hoechst Aktiengesellschaft

Cis Bio International

Ludwig Kuhlmann

Axel Steinstrasser

Karl-Heinz Bremer

Alexander Schwarz

Anton Mayer

Gerhard Seibert

Michael Magerstadt

Hans-Joachim Schroth

Dietrich Putter

Erich Oberhausen

A process for the preparation of an organ-specific substance labeled with technetium-99m The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which no unwanted Tc-99m compounds are bound to the antibody. This is achieved by using the complexing agent required for the reducing agent in an amount which is stoichiometric relative to the reducing agent.

Process for the preparation of an organ specific antibodies labeled with

Process for the preparation of an organ-specific substance labeled with

The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with �99m!-pertechnetate and a complex-stabilized reducing agent.

The invention relates to a method for labeling substances with--in particular radioactive--technetium or rhenium isotopes with the aid of N-substituted or C-substituted macrocyclic amine derivatives of the formula I and/or II ##STR1## in which R.sup.1 -R.sup.7, Y, m, n, o, p, f, g, h, i and j have the stated meanings, and to the use of these labeled substances, especially in medical diagnosis.

Method for labeling proteins with technetium or rhenium

The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.

Diagnostic aid containing an organ-specific substance labeled with

The invention relates to a process for the preparation of an organ-specific substance labeled with technetium-99m, in which an organ-specific substance, or an organ-specific substance which has been pretreated or coupled to a complexing agent for technetium-99m, is mixed with [99m]-pertechnetate and a complex-stabilized reducing agent.

A diagnostic aid for the scintigraphic visualization of malignant tumors which contains a radionuclide which is bonded by means of a complex-forming agent to the substance obtained by the enzymatic processing of murein with enzyme consisting essentially of hen's eggwhite lysozyme.

Diagnostic aid for the scintigraphic visualization of malignant tumors

Silica gels modified with amino groups or magnesium silicates are suitable carrier materials for technetium-99m generators since they retain copper(II) ions well and thus produce a copper-free eluate.

Growing community of inventors

Florsheim am Main, Germany

Ludwig Kuhlmann