Gerot-pharmazeutika Gesellschaft M.b.h.

Ludwig H Schlager

Derivatives of 5-aminomethyl-2-furanomethanol represented by formula (I), or pharmaceutically acceptable salts thereof, which possess calcium-antagonistic activity and are effective in lowering blood pressure, and a process for preparing and using the same: ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.2 ' each represent a lower alkyl group containing 1 to 4 carbon atoms, with the proviso that R.sub.2 and R.sub.2 ', together with N, may form a 5- or 6-membered saturated heterocyclic ring which may contain an additional heteroatom, selected from the group consisting of as O, N and S, or R.sub.2 ' represents an aralkyl group; wherein R.sub.3 and R.sub.4 are each selected from the group consisting of a hydrogen atom, a halogen, a nitro group and a methoxy group; and wherein R.sub.5 is selected from the group consisting of a halogen, a difluoromethoxy group, a trifluoromethyl group, a nitro group, a carbamylmethoxy group, a cyanomethoxy group and a mesyloxy group.

5-dialkylaminomethyl-2-furanomethanol derivatives having

The disclosure is directed to new 3-hydroxy-1,4-benzodiazepine-2-ones and to the process for the preparation thereof. The compounds of the invention have the structural formula ##STR1## in which R is methoxy or nitrile, R.sub.1 is hydrogen, halogen, trifluoromethyl or nitro and R.sub.2 is hydrogen or halogen, with the proviso that R is different from methoxy, if R.sub.2 is o-halogen. The compounds have marked sedative and sleep prolonging activity when evaluated in standard pharmacological procedures.

Novel 3-hydroxy-1,4-benzodiazepine-2-ones and process for the

Novel 3-Di-n-Propyl-Acetoxy-Benzodiazepine-2-Ones and use thereof as anti-convulsant compounds.

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Vienna, Austria

Ludwig H Schlager