Tel Aviv University

Tel Hashomer Medical Research Infrastructure and Services Ltd.

Technology Innovation Momentum Fund (israel) Limited Partnership

Technology Innovation Momentum Fund (isreal) Limited Partnership

Ludmila Buzhansky

Ehud Gazit

Lihi Adler-Abramovich

Zvi Nevo

Arie Orenstein

Genady Kostenich

Yoseph Salitra

Shmuel Einav

Mor Oron-Herman

Talia Shekhter Zahavi

Moran Aviv

Ulrich Abel

Michael Ioffe

Alon Sayer

Yaniv Amir

Anat Frydman-Marom

Rafael Ischakov

A formulation includes an active agent, a thickening/solidifying agent, and an antioxidant. The active agent is 9-cis-&#x3b2;-carotene (9CBC) or a derivative thereof of the following formula: where Ris H or methyl; X is optionally substituted with one or more methyl groups; n is an integer of 0-16; and the asterisk represents the point of attachment to the cyclohexene ring.

Method for synthesis of 9-cis-beta-carotene and formulations thereof

Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.

Peptide-based hydrogel particles and uses thereof

Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

Synthetic somatostatin receptor ligands

The present invention relates to a method for total chemical synthesis of 9-cis-&#x3b2;-carotene (9CBC), and further provides stable formulations thereof.

Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.

Malleable hydrogel hybrids made of self-assembled peptides and biocompatible polymers and uses thereof

Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.

Dipeptide analogs for treating conditions associated with amyloid fibril formation

Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipeptide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.

Growing community of inventors

Ariel, Israel

Ludmila Buzhansky